Nodular sclerosing Hodgkin lymphoma, khansara ya maselo amphamvu, ndi mtundu wa matenda a Hodgkin. Ndilo mtundu wofala kwambiri wa Hodgkin lymphoma m'mayiko otukuka, omwe amawerengera anthu 60 mpaka 80 peresenti ya anthu onse okhudzidwa ndi matendawa.
Nodular sclerosing Hodgkin lymphoma amakhudza makamaka achinyamata ndi achinyamata. Zimakhalanso zofala kwambiri kwa atsikana kuposa anyamata.
Dzina lakuti 'nodular sclerosing' limachokera ku maonekedwe a mitsempha yotchedwa lymph node mu microscope mu mtundu uwu wa Hodgkin lymphoma.
Zizindikiro zikuluzikulu za nodula sclerosing Hodgkin lymphoma ali ndi mitsempha yowonjezera m'khosi, pamimba kapena mkati mwa chifuwa . Matenda a lymphoma amapangidwa ndi lymph node biopsy.
Anthu ambiri amapezeka m'zaka zoyambirira ndipo amachiritsidwa ndi mankhwala omwe amaphatikizapo mankhwala a chemotherapy ndi mankhwala omwe amawathandiza.
Mmodzi mwa Zojambula Zambiri Zosiyana za Ma Hodgkin Lymphomas
Maina a mitundu yonse ya lymphoma ndi subtypes amasokoneza ngakhale madokotala omwe samawachitira nawo nthawi zonse. Matenda a Hodgkin ndi Hodgkin lymphoma amatanthawuza chimodzimodzi chinthu chomwecho, komabe, pali mitundu yosiyana ya lymphoma, yomwe Hodgkin ndi imodzi yokha. Ndipo pali mitundu yambiri ya Hodgkin lymphoma, nayenso. Kotero, apa pali kugwedezeka kwa nodular sclerosing Hodgkin lymphoma momwe zimalowera mu chithunzi chachikulu cha mafupa onse:
Mitundu iwiri ya lymphoma ndi Hodgkin ndi Non-Hodgkin lymphoma.
Hodgkin lymphoma ikhozanso kupasulidwa m'magulu awiri:
- Classic Hodgkin lymphoma - yomwe ili ndi zingapo zingapo
- Nodular lymphocyte-yaikulu kwambiri ya Hodgkin lymphoma
"Nodular lymphocyte kwambiri" ndi "nodular sclerosing" siziri zofanana - zimatchula mitundu iwiri ya Hodgkin lymphoma.
Nodular Sclerosing Hodgkin lymphoma - ndi lymphoma yomwe ikufotokozedwa - ndi gawo la Classic Hodgkin lymphoma. Classic Hodgkin lymphoma ili ndi zotsatira zinayi zotsatira:
- Zosintha zosawerengeka
- Zosakaniza zosakanikirana
- Lymphocyte-wolemera
- Lymphocyte-yatha.
Zosintha: Nodular Sclerosing Classic Hodgkin Lymphoma
Nodular sclerosis Hodgkin lymphoma (NSHL) ndiyo njira yodziwika kwambiri yochizira matenda okhudzana ndi ziwalo pakati pa achinyamata ndi achinyamata m'mayiko otukuka. NSHL imakhalanso ndi gawo lopindulitsa kwambiri, lomwe limakhala ndi chiwopsezo chokwanira 100 kwa mapasa ofanana.
Posachedwapa, panali phunziro lalikulu lomwe linagwiritsidwa ntchito pothandizana ndi dzuwa la ultraviolet kuchokera ku dzuwa komanso magawo osiyanasiyana a Hodgkin lymphoma. Mu phunziro la Emily Bowen ndi anzake ogwira ntchito, Hodgkin lymphoma matenda anali otsika kwambiri m'magulu a anthu okhala ndi dzuwa lopambana kwambiri. Ngakhale kuti izi zinali zochitika, zokhazokha, zidawoneka ngati zowona mwa anthu okhala ndi nodular sclerosis subtype.
Kafukufuku wina wam'tsogolo wakhala akufufuza njira inayake yothandizira, kutetezedwa kwa chitetezo cha mthupi, ndi momwe zingagwiritsire ntchito ndi njira zosiyanasiyana zomwe zikudziwikiratu zikuchitika mu mitundu ina ya HL.
Kafukufuku wina wa Peter Hollander ndi anzake adanena kuti kutetezedwa kwa chitetezo cha chitetezo cha chitetezo cha chitetezo cha chitetezo cha chitetezo cha chitetezo cha chitetezo cha mthupi ndi njira yatsopano yothandizira anthu odwala kachirombo ka Hodgkin lymphoma.
Kagulu kameneka kanapeza kuti maonekedwe ena a maselo omwe amapezeka kuzungulira chotupacho, osati a maselo otupawo okha, adagwirizanitsidwa ndi zizindikiro. Phunzirolo linapeza kuti zotsatira za HL zakuda zinali zoipitsitsa pamene maselo oyera a m'magazi, kapena maselo a microenvironment, anali ochuluka kwambiri kupanga PD-1 ndi PD-L1. Iwo analongosola kuti magulu a odwalawa angapindule ndi mankhwala oopsa a chemotherapy ndipo, mwina, kuchokera ku PD-1 tizilombo toyambitsa matenda.
> Zotsatira:
> Cozen W, Li D, Best T, et al. Meta-wide meta-analysis of nodular sclerosing Hodgkin lymphoma imatchula ngozi yotero pa 6p21.32. Magazi. 2012; 119 (2): 469-475.
> Hollander P, Kamper P, Ekstrom K, ndi al. MaseĊµera akuluakulu a PD-1 + ndi PD-L1 + leukocyte mu classical Hodgkin lymphoma microenvironment akugwirizana ndi zotsatira zochepa. Blood Adv. 2017; 1 (18): 1427-1439.
> Bowen EM, Pfeiffer RM, Linet MS, ndi al. Kugwirizana pakati pa miyezi yambiri ya ultraviolet ndi Hodgkin lymphoma subtypes ku United States. British Journal ya Cancer. 2016; 114 (7): 826-831.