Myelofibrosis ndi chikhalidwe chimene chimapanga (fibrosis) mu mafupa. Kupweteka uku kumapangitsa kuti mafupa anu akhale ovuta kupanga maselo a magazi mwachizolowezi.
Zizindikiro
Myelofibrosis sangayambitse zizindikiro. Komabe, zingatengedwe pa ntchito yamagazi ya chizolowezi yomwe dokotala wanu amagwira. Zizindikiro zina zimagwirizana ndi kuchepetsa maselo ofiira a magazi ( anemia ) ndi mapiritsi ( thrombocypenia ), monga:
- Kutopa kapena kutopa
- Pallor
- Dontho lofiira pa khungu lotchedwa petechiae
- Kuwonjezereka koopsa
- Kuchulukitsa magazi
- Matenda owonjezera / kapena chiwindi - mukhoza kuona chidzalo pansi pa nthiti zanu.
- Kupweteka kwa Bony
- Kutentha kapena matenda opatsirana
Amene Ali Pangozi
Myelofibrosis kawirikawiri imapezeka mwa anthu oposa zaka 50. Zitha kuchitika mwa ana koma ndizovuta kwambiri. Odwala ndi polycythemia vera kapena thrombocythemia yofunikira amatha kukhala ndi myelofibrosis.
N'chifukwa Chiyani Amuna Anu Akukula?
Nthata ndi chiwalo cha thupi, kutanthauza kuti chikhoza kupanga maselo a magazi. Mu myelofibrosis, komwe mafupa amatha kukhala ovuta kupanga maselo a magazi, nthonje imawonjezera kuyesera kupanga patsogolo.
Zimayambitsa
Myelofibrosis yapadera ndi khansa yamagazi yosazolowereka (mbali ya mankhwala osapitirira myeloproliferative neoplasms). Izi zimayambitsidwa ndi kusintha kwa chibadwa. Panthawi ino sitikudziwa chomwe chimayambitsa kusintha kwa thupi.
Myelofibrosis ikhoza kuyambitsidwa ndi zikhalidwe zina ndipo imatchedwa myelofibrosis yachiwiri.
Izi zikuphatikizapo:
- Mankhwala ena amagazi, makamaka acacychocytic leukemia (mtundu wa myeloid leukemia ) kapena myelodysplastic syndrome
- Cancer metastasis kuti fupa
- Zidzetsa matenda monga lupus, scleroderma
- Kuchepetsa matenda oopsa: Mu chikhalidwe ichi, pali kukwera kwa magazi m'mitsempha ya m'magazi m'mapapu.
- Hyperparathyroidism yokhudzana ndi kuchepa kwa vitamini D
- Matenda a galasi
- Mankhwala ochizira osteeodystrophy: Awa ndiwo vuto la mchere ndi minofu ya mitsempha yomwe imapezeka kwa odwala matenda a impso.
Kudziwa
Poyamba, kuchepa kwa magazi kumatsimikiziridwa pa chiwerengero cha magazi athunthu . Kawirikawiri, kuchepa magazi m'thupi ndi / kapena thrombocytopenia alipo. Kuwonongeka kwa maselo a magazi nthawi zambiri kumazindikiritsidwa pa pulogalamu ya magazi yowonongeka, microscope ikugwedeza dontho la magazi. Maselo ofiira ambiri nthawi zambiri amafotokozedwa ngati akuwoneka ngati teardrop.
Chizindikiro chotsiriza chimakhala ndi mafupa a mafupa, zomwe zimachitika pang'onopang'ono. Pogwiritsa ntchito udzu wapadera, mitsempha yotchedwa fibrous mu fupa la mafupa ikhoza kudziwika.
Pa ntchito yothandizira, dokotala wanu ayesa kudziwa chomwe chimayambitsa myelofibrosis. Zomwe zikuphatikizidwa pa ntchitoyi zidzakhala zoyezetsa mazenera zamasinthidwe enieni otchedwa JAK2, MPL, ndi CALR.
Chithandizo
Chithandizo chimadalira chifukwa chachikulu. Chithandizo cha myelofibrosis choyambirira chimatsimikiziridwa ndi chiopsezo cha matenda opitirira komanso kupulumuka kwapadera.
- Kuwunika: Ngati mulibe zizindikiro zazikulu, kuyembekezera kuyembekezera kungakhale njira yabwino kwambiri yothandizira.
- Kutsekemera: Kutaya magazi m'thupi ndi thrombocytopenia komwe kumawoneka myelofibrosis kungakhale koopsa ndipo kungafunike kuikidwa magazi nthawi zambiri. Nthawi zambiri kuikidwa magazi kungadziwe ngati pakufunika chithandizo chamankhwala.
- Kulowetsa mafupa a mitsempha: Chosankha chokhazikitsa ayenera kuyang'anitsitsa mosamala kuopsa ndi phindu.
- Ruxolitinib: Mankhwalawa amaletsa JAK2 angagwiritsidwe ntchito kwa odwala omwe ali ndi kusintha kwa JAK2 omwe ali ndi zizindikilo zazikulu ndipo sangagwiritse ntchito mafuta opatsirana.
- Splenectomy : Ngati nthendayo isachepetse mu kukula kwa mankhwala, ikhoza kuchotsedwa opaleshoni.
- Hydroxyurea: Hydroxyurea ndi mankhwala omwe amatha kugwiritsa ntchito kuchepetsa kukula kwa mpeni ndi zizindikiro zina.
- Mankhwala ena monga androgen ndi thalidomide
- Mankhwalawa angagwiritsidwe ntchito kuti achepetse kukula kwa nthata
Chithandizo cha myelofibrosis chachiwiri chimayang'aniridwa pa chifukwa choyambitsa. Choncho ngati myelofibrosis imayambitsidwa ndi khansara monga myeloid leukemia (AML), imachizidwa ndi chemotherapy. Ngati myelofibrosis ndi yachiwiri kwa matenda omwe amadzimadzimitsa okha, chithandizo cha matendawa chingapangitse kuti magazi awerengedwe.
Mulimonse mankhwalawa, gulu lanu lachipatala lidzakuyendetsani njira zonse zomwe mukufunikira kuti mukhale ndi thanzi lanu. Musazengereze kugawana nawo malingaliro anu, mafunso, ndi kumverera kwanu.