Phunzirani zambiri za mitundu ya Paenibacillus yovuta VT 400
M'chaka cha 2016, pamsonkhano wapachaka wa American Society for Microbiology, asayansi asonkhana kuti akambirane ndi kukambirana zokhudzana ndi dziko la mabakiteriya ndi thanzi laumunthu.
Zina mwa zomwe anapeza, gulu linafotokoza za mtundu wonse wa majeremusi, kapena majini athunthu, kuti mabakiteriya otchedwa Paenibacillus amve VT 400 (PVT400). Mabakiteriyawa anali atapezeka kale m'matumbo a mliri wa ana omwe ali ndi acute lymphoblastic leukemia (ALL).
Zomwe mwatsatanetsatane kuchokera ku maphunzirowa komanso zamtsogolo zidzawathandiza asayansi kudziwa ngati mabakiteriyawa angakhale ndi gawo mu matenda aumunthu, makamaka kwa anthu omwe ali ndi khansa ya m'magazi yomwe imakhala ndi chibayo kapena matenda a magazi.
Chibayo mwa Anthu Amene Ali ndi Khansa
Chibayo ndi chiwopsezo chachikulu cha imfa ya khansa omwe ali ndi neutropenia, makamaka omwe ali ndi khansa ya m'magazi. Neutropenia ndi chiwerengero chochepa cha neutrophils m'magazi a neutrophils ndi maselo oyera omwe ndi ofunika powathandiza thupi kulimbana ndi matenda .
Matenda opatsirana opatsirana otsika amapezeka kwambiri pakati pa odwala khansa, ndipo ena amasonyeza kuti 13 mpaka 31 peresenti ya odwala khansa ya m'magazi amalandira mankhwala a chemotherapy ndipo 80 peresenti ya odwala omwe ali ndi kachilombo koyambitsa maselo amtundu wa hematopoietic angapezepo gawo limodzi la chibayo.
Matenda a neutropenic ndi omwe angathe kupha matenda. Pa zochitika zoterezi, madokotala amayambitsa mankhwala ochiza ma antibiotic nthawi yomweyo, popanda kuyembekezera zotsatira za labotolo kuti atsimikizire ndi kufotokoza mtundu wa kachilombo ka bakiteriya-chifukwa ndi kofunika kuyambitsa chithandizo kamodzi, kuchepetsa chiopsezo kuti wodwalayo adzalandira kachilomboka.
Ndipotu, mankhwala opatsirana amagwiritsidwa ntchito pazinthu zina, zomwe zili pansipa.
Kupititsa patsogolo kumeneku mu kayendedwe ka chiphuphu cha neutropenic kumayambitsa chiyembekezo cha zotsatira zabwino. Mabungwe ambiri azachipatala apereka malangizo atsopano othandizira maantibayotiki omwe akukayikira kuti ndi neutropenic pneumonia.
Ndipo nkotheka kuti othandizira atsopano omwe amalimbikitsa mayankho a thupi ku kachilomboko akhoza kupititsa patsogolo ntchito ya maantibayotiki.
Kuganizira za tizilombo toyambitsa matenda m'matenda omwe ali ndi neutropenia
Malangizo ochokera ku American Society of Clinical Oncology (ASCO) amalimbikitsa kuti madokotala ayesetse kupewa matenda opatsirana ndi neutropenia koma alibe malungo. Chithandizo cha antibacterial ndi mankhwala osakanizidwa amalangizidwa ngati ma neutrophils akuyenera kuti akhale pansi pa 100 / μL kwa masiku oposa asanu ndi awiri. Chitsogozochi chimanena kuti chofunikiratu cha antibacterial therapy preventive therapy ndi oral fluoroquinolone, koma kuti mankhwala ophera tizilombo ndi mankhwala a triazole.
Odwala omwe ali ndi neutropenia amakhala ndi tizilombo toyambitsa matenda osiyanasiyana kuposa anzawo. Zingakhale zothandiza kwa madokotala kuti aganizire kumene mabakiteriya amachokeramo pofotokoza kuti ndi mankhwala ati omwe angakhale otsutsana nawo, choncho njira zomwe zimakhala zothandiza kwambiri.
Mitundu ya Paenibacillus
Chakumapeto kwa zimenezi, asayansi akhala akuphunzira PVT400, mabakiteriya atsopano omwe ali ndi matenda a khansa ya m'magazi, omwe ali m'gulu la Paenibacillus-mtundu wa mabakiteriya opangidwa ndi ubongo. Mitundu yosiyana mkati mwa gululi yakhala yolekanitsidwa ndi dothi, madzi, zomera, mkaka, ndi malo ena.
Komabe, mitundu ya Paenibacillus sinadziwika kuti imayambitsa matenda a anthu. .. mpaka malipoti aposachedwa amasonyeza kuti mwina pali mitundu itatu ya mitundu ya Paenibacillus yosiyana mu matenda aumunthu.
PVT 400 itathapatsidwe pamatenda a wodwala odwala matenda oopsa a khansa ya m'magazi , kafukufuku oyambirira anawonetsa zofanana za mitundu imeneyi ndi mitundu ya amylolyticus, yomwe imapezeka mu ntchentche yotchedwa hindgut ya ntchentche; Komabe, pakadali pano, zidali zowona kuti P. amylolyticus siinapezedwe mwa anthu, ndipo kafukufuku wina wasonyeza kusiyana pakati pa mabakiteriya a VT 400 omwe amapezeka mu wodwala khansa ndi P. zina.
amylolyticus mavuto.
Kotero, pamene ofufuza ankafufuza lonse mtundu wa ma 400 VT, panali zochitika zambiri zosangalatsa. Anali ndi majeremusi omwe amatha kukana njira zochizira mankhwala, monga tunicamycin ndi bleomycin. Anapezanso majeremusi a mapiritsi a bakiteriya omwe amatsutsana ndi mankhwala osokoneza bongo, komanso majeremusi osakaniza antibiotics, kuphatikizapo vancomycin, fosmidomycin, tetracycline komanso mankhwala a penicillin, kapena beta-lactams.
Olemba za kafukufukuyu anapeza kuti zochitika zapachiyambi za Paenibacillus sp. Vuto la VT 400 lidzakuthandizira kudziwa kuti Paenibacillus ali ndi matenda otani muumunthu komanso amadziwika kuti ali ndi mabakiteriya omwe amakhala ndi odwala matenda a khansa.
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