Mapiritsiwa amapezeka kuti sagwiritsidwe ntchito moyenera
Pamsonkhano wa 2017 wa American Thyroid Association, ochita kafukufuku angapo anafotokoza za kafukufuku watsopano zomwe zasonyeza kuti levothyroxine yamadzi imathandiza kwambiri kusiyana ndi mapiritsi pochiritsa magulu ambiri a odwala.
Levothyroxine ndi mawonekedwe opangidwa ndi mankhwala a thyroxine (T4), mahomoni ofunika ochitidwa ndi chithokomiro. Levothyroxine ndi mankhwala opatsirana kwambiri a hypothyroidism, chithokomiro chosagwiritsidwa ntchito kwambiri chomwe chimapezeka chifukwa cha chithokomiro chochotsa chithokomiro, kupuma kwa radioactive, ndi kuwonongeka kwa mankhwala chifukwa cha matenda omwe amachititsa kuti matenda a Hashimoto a thyroiditis asinthe.
Generic levothyroxine, komanso mayina odziwika bwino monga Sythroid ndi Levoxyl, ndiwo ma tebulo a mankhwala otchedwa thyroid . Pulogalamu ya levothyroxine ndiyo njira yaikulu kwambiri yomwe mankhwalawa amatengedwa.
Kwa zaka zingapo, mtundu wa levothyroxine wamadzimadzi wa softgel wakhala ukupezeka ku United States pansi pa dzina lakuti Tirosint . Mtundu wa Tirosint wa levothyroxine wapangidwa makamaka ngati hypoallergenic, mtundu wapadera wa levothyroxine kwa anthu amene ali ndi vuto lakumimba kapena m'mimba, kuvutika ndi kumwa mankhwala a chithokomiro, kapena kupweteka kwa mankhwalawa ndi kumangiriza mu pulogalamuyi ya mankhwala a levothyroxine.
Mu February wa 2017, a FDA anavomereza levothyroxine, Tirosint-SOL. Liquid levothyroxine yakhala ikupezeka ku Italy kuyambira mu 2012. Madzi a levothyroxine anali ngati njira ina kwa odwala omwe sangathe kumeza, omwe amadyetsedwa ndi chubu, komanso ana omwe ali ndi hypothyroidism.
Tirosint-SOL ikuyembekezeka kukhalapo pamsika wa US ku 2018.
Levothyroxine ndi Mafuta
Pa kafukufuku wina, akatswiri ofufuza a ku Italy anasonyeza kuti levothyroxine yamadzi amadziwika bwino ndi mapiritsi. Iwo anafufuza gulu la odwala omwe amatenga mapiritsi a levothyroxine, omwe, ngakhale kuti kuchuluka kwa mlingo kumawonjezeka, analibe tizilombo toyambitsa timadzimadzi (TSH) ndi ma t4 aulere m'zinthu zolembera.
Ofufuzawa anasintha odwalawo kuti apite kwa mlingo womwewo wa madzi kapena softgel levothyroxine ndipo anawatsitsimutsa chithokomiro chawo. Iwo adapeza kuti 85 peresenti ya odwala omwe adaphunzira anawonetsa kusintha kwakukulu m'mawili awo a TSH ndi ma T4 awo omasuka. Masabata angapo atayamba levothyroxine madzi, odwala hypothyroid adatha kufika pamatenda a chithokomiro m'magulu owonetsera.
Akatswiriwa anapeza kuti mankhwala a levothyroxine amakhala ndi zotsatira zabwino kwambiri poyerekeza ndi mapepala opangidwa ndi odwala ena.
Pambuyo pa Thyroidectomy, Softgel Capsules Zothandiza kwambiri
Mu kafukufuku wina, ofufuza anayerekezera kupambana kwa mapiritsi a levothyroxine ndi softgels kwa odwala omwe anali ndi chithokomiro chonse cha goiter. Odwalawa analibe vuto lililonse la mankhwala.
Pafupifupi theka la odwala anapatsidwa mapiritsi, ndipo theka lina analandira makapisozi a softgel pa matenda omwewo, atangoyamba opaleshoni ya chithokomiro. TSH ya odwala, thyroxine (FT4) yaulere, ndi ma triiodothyronine (FT3) omasuka anayesedwa pambuyo pa masabata asanu ndi limodzi ndi pambuyo pa milungu 12.
Pa masabata onse awiri ndi asanu ndi awiri, odwala omwe amatenga makapisozi a softgel anali ndi magulu a TSH ochepa kwambiri.
Pazigawo ziwirizo, chiwerengero cha odwala omwe adakweza mazinga a TSH pamwamba pa 3.5 mcU / ml-hypothyroid omwe adachitidwa pa phunziroli-anali apamwamba kwambiri kwa odwala omwe amalandira mapiritsi. Ofufuzawo anapeza kuti ngakhale odwala omwe analibe vuto la mankhwala kapena kugaya, levothyroxine softgel capsules anali othandiza kwambiri.
Bwino TSH Control TSH Pambuyo Khansa
Kuphunzira kwina ku Italy kunayang'ana odwala omwe ali ndi khansa yosiyana (DTC) yotenga levothyroxine. Malingana ndi American Thyroid Association, odwalawa ayenera kukhala ndi TSH pakati pa 0.1 ndi 0,5 mU / L-pansi pa mapeto a tsambalo-kuteteza kupewa kanseri ya chithokomiro.
Chifukwa ichi ndiwindo lochepetsetsa, ndikofunikira kuti mankhwala a levothyroxine akhale osasunthika pokhala ndi TSH mlingo.
Ofufuzawo anayerekezera kusiyana kwa TSH mlingo kwa odwala opaleshoni ndi levothyroxine, ndi mapiritsi. Theka la odwala analandira madzi levothyroxine, ndipo theka analandira piritsi, ndipo onse anali ndi mlingo womwewo wa mankhwala a chithokomiro. Miyeso yambiri ya ma TSH yachitika.
Ofufuzawa adawona kuwonjezeka kwakukulu kwa maselo a TSH kwa odwala omwe amatenga mapiritsi, poyerekeza ndi omwe amatenga levothyroxine. Mwachidziwitso, pafupifupi 16 peresenti ya odwala pa mapiritsi sanakwaniritse mtundu wa TSH, poyerekezera ndi 4 peresenti ya iwo omwe ali pa levothyroxine. Ofufuzawo anapeza kuti kugwiritsa ntchito LT4 levothyroxine poyerekeza ndi mapiritsi kunayambitsa chiwerengero chokwanira kwambiri cha odwala khansa omwe amatha kukhala ndi makhalidwe abwino a TSH omwe amawathandiza kuchepetsa chiopsezo cha khansa kubwerera.
About Zamalid Levothyroxine
Monga taonera, ku US, mankhwala opangidwa ndi malonda a levothyroxine amapezeka ku Tirosint brand softgel capsules, komanso ku Tirosint-SOL madzi. Tirosint ilibe shuga, utoto, mowa, tirigu wosakaniza (gluten), lactose, mthethe , kapena zina zina zomwe zimagwiritsidwa ntchito popanga mapiritsi a levothyroxine. Zosakaniza zokhazokha m'ma capsules ndi levothyroxine, gelatin, glycerin, ndi madzi, zomwe sizikhoza kusokoneza kutentha kapena kuyambitsa matenda. Tirosint-SOL ili ndi levothyroxine yokha.
Tirosint wakhala yosungidwa makamaka kwa odwala omwe ali ndi matenda monga Crohn's disease kapena matenda omwe amachititsa kuti thupi lawo likhale lopweteka kwambiri. Chifukwa ndi hypoallergenic, imagwiritsidwanso ntchito ndi odwala omwe amadziwika kuti ali ndi zofukiza kapena zowonjezera zomwe zimagwiritsidwa ntchito popanga maina ndi mapiritsi a generic levothyroxine.
Zina zinapindula ndi mavitamini a Tirosint: chakudya, calcium , chitsulo, khofi , ndi mkaka sizikuwoneka kuti zingasokoneze kutulutsa madzi a levothyroxine, monga momwe amachitira ndi mapiritsi.
Chifukwa cha udindo wake monga mankhwala apadera kwa omvera ochepa, ndipo chifukwa Tirosint ndi okwera mtengo kwambiri kuposa ma brand ena a levothyroxine kapena mapiritsi akuluakulu, izi siziyenera kugwiritsidwa ntchito kwambiri kwa mankhwala a hypothyroidism ku United States.
Mawu Ochokera
Kafukufukuyu akusonyeza kuti odwala ambiri-osati okhawo omwe ali ndi malabsorption kapena chifuwa- angapindule ndi kutembenuka kuchoka ku mitundu ya levothyroxine pulogalamu ya levothyroxine. Kafukufuku wina wofalitsidwa m'nyuzipepala yotchedwa RD Diet anapeza kuti pakati pa odwala 1,000 amene amatenga levothyroxine, 15 peresenti anali ndi chifuwa chokwanira ndi mankhwala ena opezeka m'mapiritsi a levothyroxine.
Pali mavuto ena omwe angapangitse kusintha kuchokera pulogalamu ya levothyroxine kupita ku Tirosint softgel capsules kapena Tirosint-SOL madzi, komabe:
- Dokotala wanu mwina sangadziwe ma capsules a Tirosint kapena Tirosint-SOL madzi monga zosankha.
- Inshuwalansi yanu, HMO, kapena chithandizo china chaumoyo sangakhale okonzeka kulipira kapena kubwezera kwa Tirosint. Pachifukwa ichi, mungafunike mthandizi wanu wa zaumoyo kuti mukhale ndi "kulembetsa zolembedwa" kapena "osalowetsamo" kapena "palibe".
- Ngati mumayenera kulipira, ndalama zosiyana-zomwe zingakhale madola 50 mpaka $ 100 kapena kuposa mwezi uliwonse-zingapangitse kusintha kukuletsani ndalama.
Komabe, ngati mukuvutika kuti mukwaniritse chithandizo chanu cha chithokomiro kapena kuyesetsa kuti mukhale ndi zizindikiro za hypothyroidism, mungafunike kukambirana ndi wothandizira zaumoyo wanu ngati mukufuna kusintha mankhwala anu.
> Zotsatira:
> Benvanga, S. ndi al. "L-Thyroxine mu Mlomo Wa Mlomo kapena Softgel Formulation Imapangitsa Sitium Yowonjezeka Yambiri ya T4." Chithokomiro. October 2017, 27 (S1): A-166-A-188.
> Fallahi, P et. al. "Lipoti la Thyroxine mu Gel Capsule Pogwiritsa Ntchito Pulogalamuyi Pogwiritsa Ntchito Odwala Onse Operekedwa ndi Matenda Onse a Chithokomiro." Chithokomiro. October 2017, 27 (S1): A-166-A-188.
> McMillan M, Rotenberg K, ndi al. Mankhwalawa, mankhwala osokoneza bongo, ndi zakudya monga zinthu zokhudzana ndi mankhwala a levothyroxine: zotsatira za Project CONTROL monitoring. Mankhwala Osokoneza Bongo RD. 2015. December 21.
> Pirola, I. et. al. "TSH Kusintha kwa Odwala Amene Amakhudzidwa ndi Khansa ya Chithokomiro Yosiyana ndi Levothyroxine Wothetsera Zamadzimadzi kapena Ma Tablet." Chithokomiro. October 2017, 27 (S1): A-166-A-188.
> Sevilla Alsina, ME ndi. al. "Njira Yophatikizira Njira Yopangira Chithandizo cha Hypothyroidism Pambuyo Kuthandizidwa kwa Mlomo Levothyroxine." Chithokomiro. October 2017, 27 (S1): A-166-A-188.