Kusokonezeka kwa Estrogen: Kuchiza Kutha Kusamba Kwambiri
Chaka chilichonse amayi ambiri a zaka zapakati pa 15 ndi 44 amapeza "Estrogen Crash", ndipo mwadzidzidzi amasiya majeremusi omwe amasiya amayi kuti ayambe kusamba. Ngakhale kuti kusamba kwazimayi kumaoneka ngati vuto kwa amayi achikulire, atsikana ambiri omwe ali ndi vuto loyamba kusamba amadziona okha osakonzekera kusintha kosadabwitsa komwe kumachitika.
Kuwonongeka kwa Estrogen kumachitika pamene mazira a mkazi amachotsedwa kapena mwadzidzidzi amasiya kugwira ntchito. Izi zikachitika thupi limasiya kubala estrogen .
"Mwachidziwikire, amayi am'maopaleshoni amachepetsa pang'ono pa maseŵero a estrogen kwa zaka ziwiri kapena khumi. Koma kusiyana kwa azimayi achichepere omwe amayamba kuchepa kwa thupi kapena kuchepa kwa ovunda amapewa mwadzidzidzi," adatero Dr. Lila Nachtigall, MD, Mtsogoleri a Women's Wellness Division ku Sukulu ya Zamankhwala ya New York University. "Zotsatira zake ndi kubwera kwadzidzidzi kwa zizindikiro za vasomotor: kutentha kwa moto, kutuluka usiku, kugwedezeka kwagona tulo komanso kuuma kwa amayi."
Azimayi oposa theka la milioni amachita zachiwerewere chaka chilichonse ku United States ndipo pafupifupi theka la zisokonezo zimaphatikizapo oophorectomy pakati pawo - kuchotsedwa kwa mazira ochuluka. Amayi oposa 20% omwe amapita ku maiko oposa makumi anayi aliwonse ali ndi zaka 40. Pa amayi 100 alionse, amayi amodzi amatha kukhala ndi vuto la ovari asanafike zaka 40.
Kusuta kwa mimba vs. Estrogen Crash
Azimayi omwe amatha msinkhu wa msinkhu wa msinkhu amayamba kusamba kwambiri kusiyana ndi akazi omwe amatha kusamba kumene akakula. Pofika kumapeto kwa thupi, maseŵero a estrogen amatsika pang'onopang'ono kwa zaka 2 mpaka 10, pamene opaleshoni ya amayi amatha kukumana mwadzidzidzi ndi estrogen.
Dr. Lila Nachtigall anati: "Kawirikawiri, mayi amene amadwala matendawa amayamba kusamba," adatero Dr. Lila Nachtigall. "Ndizopita patsogolo kwambiri, wodwalayo akhoza kukhala ndi mwezi umodzi wokha pano kapena apo." Koma ngati vuto la oophorectomy lachiwiri, zotsatira zake ndizovuta kwambiri komanso odwala, makamaka, akhoza kuchitapo kanthu. "
Muzochita za Dr. Nachtigall, amayi 100% opanga opaleshoni ya amayi odwala opaleshoni anali ndi zizindikiro zapadera ndipo 90% mwa amayiwa anali ndi zizindikiro zoopsa zomwe zinatha zaka 8.5. Mosiyana ndi zimenezi, pamene 85% mwa amayi omwe ali ndi chizoloŵezi chowopsa amatha kutentha, koma pafupifupi 15% amakhala ndi zizindikiro zoopsa. Panthawi yomwe amayi amafika kumapeto kwa thupi, pafupifupi 43 peresenti amafotokoza mozama kuti zizindikiro zazikulu zomwe zimatsitsa pambuyo pa zaka ziwiri.
Azimayi omwe amatha kusamba mwadzidzidzi pambuyo pa oophorectomy m'mayiko ena nthawi zambiri amadwala mwamsanga atatha opaleshoni kuti amalize mapiritsi. Kawirikawiri madokotala amapereka chilonda cha estrogen chomwe chimavala pagalasi ndipo amapereka estrogen kudzera mu khungu kupita m'magazi kwa masiku ambiri. Kupindula kwa estrogen patch ndi kubwezeredwa kwake kwa nthawi.
Zing'onozing'ono mwazigawozi ndi Vivelle-Dot. Mlingo wa .05 mg / tsiku ndi kukula kwa sitampu ya positi ndipo pafupifupi 75% yaing'ono kuposa maestrogen.
Amayikidwa pamimba pamunsi kumene amapereka estradiol kudzera mu chikopa cha khungu kupita m'magazi. Estradiol ndizofunika kwambiri ndi estrogen yopangidwa ndi mazira. Vivelle-Dot amasinthidwa kawiri mlungu uliwonse ndipo amatha kupyolera mumvula, kusambira, ndi ntchito zina za tsiku lililonse popanda kuchoka. Chigambachi chimapereka mpumulo kuchokera kutentha, kutuluka kwa usiku, ndi zizindikiro zina za Estrogen Crash kapena kusamba kwa thupi.
Vivelle-Dot imapezeka mu mphamvu zina zitatu; .0375, .075, ndi .1 mg / tsiku. Zomwe zimayambitsa mavutowa ndizopwetekedwa mtima komanso kupweteka kwa khungu pang'ono. Zochitika zowononga ndi Vivelle (R) * (estradiol transdermal system) ndi placebo, pambaliyi, zimaphatikizapo mutu (36% vs. 30%), kutentha kwa mimba (4.9% vs 1.1%), ndi kusungira madzi (3.8% vs.2.2%).
Odwala ena omwe amagwiritsa ntchito Vivelle-Dot (TM) 0.0375 mg / tsiku akhoza kuyamba kuchedwa kwachangu.
Azimayi ena sayenera kugwiritsa ntchito estrogens. Izi zimaphatikizapo amayi omwe amadziwika kapena akudziwika kuti ali ndi mimba, matenda osapatsirana achibadwa, khansa ya m'mawere, neoplasia yogwirizana ndi estrogen, thrombophlebitis yogwira ntchito kapena matenda a thromboembolic, kapena mbiri yakale ya zinthu izi. Estrogens akuti awonjezera chiopsezo chotchedwa endometrial carcinoma m'mayi am'mawopaopausal.
W. Neil Jones, Chief Executive Director Marketing and Sales of Noven Pharmaceuticals, Inc. akuti ailesi ndi mauthenga a zaumoyo ayenera kuthandiza atsikana achichepere kumvetsetsa zotsatira za Estrogen Crash kuti athe kupanga chisankho choyenera ngati akukumana ndi kusamba kwa nthawi yoyambirira.
Vivelle-Dot (TM) imagulitsidwa ndi Novogyne Pharmaceuticals, mgwirizano pakati pa Novartis Pharmaceuticals Corporation ya East Hanover, New Jersey, ndi Noven Pharmaceuticals, Inc. ku Miami, Florida.
Chiyambi choyambirira (Vivelle) (R) chomwe chinayesedwa m'mayesero a zamakono zakhala zikukonzedweratu kuti chichepetse kukula kwa chigwirizano ndikukonzekera koyamba (Vivelle-Dot) (TM) ikuwonetseratu kukhala yofanana ndi chiyambi choyambirira.
Chitsimikizo: PRNewswire / NEWSdesk