Madokotala ambiri amakhulupirira kuti proton-pump inhibitors (PPIs) omwe amagwiritsidwa ntchito nthawi yaitali ngati Prevacid (lansoprazole) ndi Prilosec (omeprazole) ya matenda a reflux (kupweteka kwa mtima) amachititsa kuti thupi likhale lopweteka (makamaka, corpus) m'mimba. mwa anthu omwe ali ndi matenda a H. pylori . Zindikirani, matenda a H. pylori angabweretse zilonda za m'mimba komanso ngakhale khansa ya m'mimba.
Kuwonjezera pa kusokoneza kutengeka, matenda aakulu a atrophic gastritis amatha kukhala ngati chithunzithunzi chodziwika bwino chomwe chimapangitsa munthu kukhala ndi khansa ya m'mimba (ie, adenocarcinoma).
Poganizira kuti mankhwala omwe amagwiritsidwa ntchito nthawi yaitali monga Prevacid ndi Prilosec amachititsa kuti anthu azidwala khansa ya H. pylori , motero amachititsa kuti chiwindi cha m'mimba chikhale choopsa kwambiri.
Chronic Atrophic Gastritis
Matenda osokoneza bongo amatha kutentha kwambiri m'mimba. Izi zimachitika kawirikawiri kwa anthu achikulire koma zingachitike ndi achinyamata. Kwa anthu ambiri, H. pylori , mabakiteriya omwe amachititsanso zilonda zam'mimba, amachititsa atrophic gastritis, nawonso. Zina zomwe zimayambitsa matendawa zimaphatikizapo matenda omwe amachititsa kuti thupi lawo liwonongeke, kutentha kwa magazi, komanso chilengedwe.
Matenda osakanikirana omwe amachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda timene timayambitsa matenda osokoneza bongo komanso maselo akuluakulu omwe amachititsa kuti tizirombo toyambitsa matenda komanso tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda.
Gastric acid ndi chapamimba chamadzimadzi amayenera kuti chimbudzi chikhale. Pamene maselo awa amatha, mavuto okhudzana ndi chimbudzi amayamba kuphatikizapo kuchepa kwa cobalamin (vitamini B12), kuperewera kwa iron ndi kuchepa kwa matenda komanso chifukwa cha zakudya zomwe timadya.
Vuto la Vitamini B12 ndilo lalikulu kwambiri la mavutowa ndipo lingayambitse mavuto a ubongo kwa anthu omwe ali ndi vuto la kuchepa kwa magazi kapena matenda omwe amatha.
Kwa anthu omwe amapanga ma PPI kwa nthawi yayitali, kusowa kobalabala sikusowa; Komabe, kachilombo ka HIV kamakula kwambiri. Zindikirani, chapamimba cha asidi chipha mabakiteriya mu chakudya chathu, ndipo pamene pali chochepa chapamimba cha asidi chifukwa cha PPIs, mabakiteriya amakhalabe osalimba ndipo amatha kuchiza mosavuta.
Matenda osokoneza bongo amachititsa mantha kwambiri chifukwa amachititsa munthu kukhala ndi khansa ya m'mimba yomwe imapha komanso imayambitsa matenda osokoneza bongo.
Njira Yopangidwa ndi Atrophic Gastritis ya PPI mwa Anthu Amene Ali ndi H. Pylori
Mapulogalamu a PPI monga Ntchito Prevacid ndi Prilosec poletsa kubereka kwa m'mimba. Matenda a reflux a gastroesophageal (GERD kapena "acid reflux") amapezeka pamene mankhwala otsika otchedwa sophgeal sphincter amalephera kutseka bwino, ndipo chapamimba cha m'mimba chimachokera m'mimba kumayambitsa kupweteka kwa mtima. Ndi zochepa za m'mimba ya asidi, kumverera kwa kupweteka kwa mtima kumakhalabe.
Pamene miyeso ya m'mimba ya asidi imachepa, mavitamini a bile amakhala osungunuka kwambiri. Mitengo ya acile imakhala yambiri , ndipo kumadera otsika kapena m'munsi mwake (pafupi ndi katumbo kakang'ono), kuwonjezeka kwa ndondomeko yamchere ya mchere imapangitsa kuti chilengedwecho chisasokoneze kukula kwa nyamakazi ya H. pylori . Komabe, pafupi kapena kupitirira mmimba, ma PPI amapanga zinthu zabwino kuti kukula kwa H. pylori .
Mwachindunji, mawonekedwe abwino kwambiri a mitundu yosiyanasiyana pakati pa mankhwala osungunuka ndi maselo a m'magazi aumunthu, omwe amachititsa kuti thupi liziyenda bwino ; motero, H. H. pylori kusamukira kwina ku chipinda chapakati chakumtunda.
Mwa kuyankhula kwina, malingana ndi njirayi, kugwiritsa ntchito kwa nthawi yaitali kwa mapulogalamu a PP kumapangitsa kuti thupi likhale malo abwino kwambiri a H. pylori mabakiteriya. Matendawa a H. H. pylori ndiye amachititsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda timene timayambitsa matenda a khansa m'mimba.
Mankhwala monga Prevacid ndi Prilosec amapezeka mosavuta pa-counter, ndipo anthu ambiri amadzipangira okha mankhwala. Ngakhale kuti ma PPI amakhala otetezeka komanso ogwira mtima pochiza GERD, ngati cholinga cha H. pylori- chokhazikika pamtundu wa gastritis ndi zoona, ndiye Ndibwino kuti muthe kukaonana ndi dokotala musanayambe kumwa PPIs kwa nthawi yaitali.
Mwapadera, dokotala wanu angakonde kukuyesani kwa H. pylori matenda ndikukuchititsani matenda otere (ie, mankhwala atatu) musanakupangitseni mankhwala a PPI a nthawi yaitali.
Tsopano, tiyeni tiponyedwe mokhoza wamphongo mu ndondomeko iyi. Mu kafukufuku wa Cochrane wa 2014, ofufuza adalemba deta kuchokera ku mayesero asanu ndi awiri (1789 of research) omwe adafufuza kuti awonetsetse kuti ma PPIs sanaonjezere chiopsezo cha matendawa . Ngati ma PPS sangaonjezere chiopsezo cha mimba ya mimba, ndiye kuti sipadzakhalanso chotupa chodziwika bwino chomwe chingathe kukhazikitsa sitepe ya khansa ya m'mimba.
Mawu Ochokera
Pamapeto pake, ngati inu kapena munthu amene mumamukonda ali ndi kupweteketsa mtima komwe kumapitirirabe, ngakhale kuti zonse zomwe tazilemba pano, ndibwino kuti tiwone dokotala. Mulole dokotala wanu asankhe ngati angakugwiritseni ntchito mankhwala a PPI a nthawi yaitali. (Muzimasuka, komabe, kuti mufunse za H. pylori kuyesa ndi kuchiza.) Chifukwa chakuti mankhwala amapezeka mosavuta pa-counter-sizitanthauza kuti muzitenga popanda kufunsa dokotala makamaka kwa nthawi yaitali.
> Zotsatira:
> Barrett KE. Mutu 3. Zosamalidwa Zachiwerewere. Mu: Barrett KE. eds. Matenda a m'mimba, 2e. New York, NY: Hill ya McGraw; 2014.
> Kitagawa Y, Dempsey DT. Mimba. Mu: Brunicardi F, Andersen DK, Billiar TR, Dunn DL, Hunter JG, Matthews JB, Pollock RE. eds. Mfundo za Schwartz za Opaleshoni, 10e . New York, NY: Hill ya McGraw; 2014.
> Mukaisho, K, ndi al. Matenda a gastritis omwe amachititsa kuti mankhwala a PPI apitirire ku Helicobacter Pylori- odwala omwe ali ndi HIV. World Journal of Gastroenterology . 2014; 20 (34): 11962-5
> Nyimbo, H, Zhu, J, Lu, D. Nthawi yaitali ntchito ya proton pump inhibitor (PPI) ndi chitukuko cha zilonda zam'mbuyo. Dongosolo la Cochrane la Zosintha Zogwirizana. 2014.