Madzi amphesa amadziwika kuti amagwirizanitsa ndi mankhwala angapo , kuonjezera zotsatira zake ku ma soya ambiri. Choncho, pankhani ya Plavix (clopidogrel), mankhwala ochepetsetsa magazi omwe amachepetsera kufalikira kwa matenda a stroke ndi myocardial infarction, kodi ndibwino kuti adye madzi a chipatso? Yankho lalifupi ndilo "ayi."
Kodi Madzi a Mphesa Amagwirizana Bwanji ndi Plavix?
Phunziro la 2014 lomwe linapeza madzi a mphesa amalepheretsa mapuloteni a CYP3A4, omwe clopidogrel ndi gawo lapansi, ndi enzyme ya CYPC19, yomwe imayambitsanso mankhwalawa.
Mphesa yamphesa ikhoza kusokoneza kutembenuka kwa clopidogrel ku mawonekedwe ake, motero kuchepetsa mankhwala a antiplatelet kwenikweni oyenera kuti tipewe kupwetekedwa kapena kupweteka kwa mtima.
Mu thupi, clopidogrel imagwiritsidwa ntchito poyesa kugwiritsa ntchito njira ya CYP2C19. Komabe, anthu ena ndi osauka magetsi a CYP2C19 enzyme. Anthu awa akulimbana ndi clopidogrel. Ngakhale kuli koyezetsa magazi kuti mudziwe odwala clopidogrel osagwiritsidwa ntchito mankhwalawa, mayesowa sagwiritsidwa ntchito kwambiri. Zindikirani, anthu omwe ali osauka a clopidogrel metabolizers, amakhalanso ndi chiwopsezo chokwanira cha kufa kwa zochitika za mtima kapena matenda a thrombosis.
Malingana ndi lipoti la FDA, mankhwala ena amtima omwe amathirira madzi pamadzi ndi awa:
- statins (monga Zocor ndi Lipitor)
- Mankhwala a magazi monga nifedipine
- mankhwala odana ndi arrhythmia monga amiodarone
Kuwonjezera pa mankhwala a mtima, madzi a zipatso amathanso kumakhudza mankhwala awa:
- mankhwala omwe amagwiritsidwa ntchito popanga thupi monga cyclosporine
- mankhwala osokoneza bongo monga buspirone
- antihistamines ngati Allegra
Mphuzi yamtengo wa zipatso amatha kukhala gawo labwino la zakudya zilizonse. Ngati muli ndi mankhwala amtima, chonde kambiranani ngati ndibwino kumwa zakumwa zam'madzi ndi dokotala wanu kapena wothandizira zaumoyo.
Onetsetsani kuti muwadziwitse wothandizira zaumoyo wanu mankhwala onse omwe mukuwatenga ndi mlingo wa mankhwalawa.
Mawu Ochokera
Nthawi zonse ndibwino kuti muwerenge mosamala zolemba zomwe zimabwera ndi clopidogrel. Payenera kukhala gawo pa zokhudzana pakati pa clopidogrel ndi mankhwala ena. Ngati simunalandirepo phukusi, funsani azimayi anu kuti mupangeko.
Ngati mukugwiritsa ntchito mankhwala owonjezera-o-counter (oTC) kapena zakudya zowonjezerapo zakudya, muyenera kulankhula ndi wamankhwala anu ndi dokotala za momwe mungagwiritsire ntchito. Muyenera kukhala osamala kwambiri pogwiritsa ntchito mankhwala opweteka monga ibuprofen ndi OTC zowonjezeretsa zomwe zili ndi ginkgo. Zotsatira za mankhwalawa zimachotsa magazi.
> Zotsatira:
> Holmberg MT, Tornio A, Neuvonen M, Neuvonen PJ, Backman JT, Niemi M. Madzi a mphesa amaletsa kugwiritsa ntchito kachipangizo ka clopidogrel. Clin Pharmacol Ther . 2014 do: 10.1038 / clpt.2013.192
> Krasowski MD. Pharmacogenomics. Mu: South-Paul JE, Matheny SC, Lewis EL. eds. Kufufuza Koyamba ndi Kuchiza: Family Medicine, 4e . New York, NY: Hill ya McGraw; 2015.
> Trevor AJ, Katzung BG, Kruidering-Hall M. Pharmacogenomics. Mu: Trevor AJ, Katzung BG, Kruidering-Hall M. eds. Katzung & Trevor's Pharmacology: Kupenda & Kubwereza Bungwe, 11e . New York, NY: Hill ya McGraw; 2015.