Mchitidwe wa Pierre Robin (kapena matenda) ndi chibadwa chomwe chimaphatikizapo kuphatikizapo zinthu zotsatirazi zomwe ziripo pa nthawi yobadwa:
- chochepa kwambiri underdeveloped m'munsi chifuwa (ichi chimatchedwa micrognathia)
- phala palate ndipadera kuti palibe mlomo wamakhwa, kawirikawiri kavalo kapena mawonekedwe a U
- chikwangwani chokwera kwambiri
- lilime lomwe limayikidwa kutali kwambiri pammero ndipo lingalepheretse kupititsa patsogolo kupuma (glossoptosis)
- pafupifupi 10-15 peresenti ya milroglossia (lilime lalikulu losazolowereka ), kapena ankyloglossia (tongue tie) angakhalepo
- mano amapezeka panthawi ya kubadwa ndi malingaliro a mano
- matenda obwera kawirikawiri
- auricular anomalies (75 peresenti ya milandu)
- Kutaya kwakumva (60 peresenti ya milandu - kawirikawiri imayendetsa)
- ndondomeko yapamwamba yowonongeka yachitsulo (rare)
- Ziphuphu zina zimaphatikizapo zosavuta m'mathambo a khutu, mkati mwa ngalande , komanso m'madzi
- ziphuphu zamphongo (zosawerengeka)
Zopweteka izi pa nthawi yobadwa nthawi zambiri zimabweretsa mavuto a kulankhula kwa ana okhala ndi dongosolo la Pierre Robin. Pa 10-85 peresenti ya machitidwe ena mawonetsedwe owonetserako akhoza kuchitika kuphatikizapo:
- Matenda a maso (hypermetropia, myopia, astigmatism, corneal sclerosis, matenda osokoneza bongo)
- Matenda a mtima atchulidwa pa 5-58 peresenti ya milandu (kukhumudwa kwa mtima, patent ductus arteriosis, patent foramen ovale, matenda a atal septal, ndi pulmonary hypertension)
- Matenda a musculoskeletal amadziwika kawirikawiri (70-80 peresenti ya milandu) ndipo angaphatikizepo syndactyly, polydactyly, clinodactyly, ndi oligodacly, clubfeet, malingaliro osakanikirana, hip anomalies, kneeosis, scoliosis, kyphosis, lordosis, ndi zina zosafunikira za msana
- Zovuta m'katikatikatikati za mitsempha ya m'magazi zimapezeka pafupifupi 50% za milandu ndipo zikhoza kuphatikizapo: kuchedwa kwachitukuko, kuchedwa kwa mawu, hypotonia, ndi hydrocephalus.
- Zovuta za mtundu wa Genitourinary ndizochepa koma zimaphatikizapo mayesero osasinthika, hydronephrosis kapena hydrocele.
Chiwerengero cha Pierre Robin chiwerengero ndi pafupifupi 1 mwa ana asanu ndi atatu (8500) obadwa, omwe amakhudza amuna ndi akazi mofanana. Mchitidwe wa Pierre Robin ukhoza kuchitika mwa iwo wokha koma umagwirizanitsidwa ndi zizindikiro zina zamtundu kuphatikizapo: Matenda a Stickler, Matenda a CHARGE, Shprintzen syndrome, Mobius syndrome, matenda a trisomy 18, matenda a trisomy 11q, kuchotsa matenda a 4q, ndi ena.
Pali ziphunzitso zitatu zomwe zimayambitsa ndondomeko ya Pierre Robin. Choyamba ndi chakuti mandibular hypoplasia imapezeka pa sabata la 7-11 la mimba. Izi zimachititsa kuti lilime likhale lalitali m'makamwa omwe amaletsa kutsekedwa kwa mapepala a palatal ndipo amachititsa kuti ukhale wofanana ndi U. Kuchuluka kwa amniotic madzi kungakhale chinthu.
Nthano yachiwiri ndi yakuti pali kuchedwa kwa chitukuko cha ubongo wa zilankhulo, zipilala zapakati, ndi palate pamodzi ndi kuchedwa kwa kayendedwe ka mitsempha ya hypoglossal. Nthano iyi ikufotokozera chifukwa chake zizindikiro zambiri zimatsimikizira pafupifupi zaka zisanu ndi chimodzi.
Nthano yachitatu ndi yakuti vuto lalikulu limapezeka pa chitukuko chomwe chimayambitsa matenda a rhombencephalus (a hindbrain - gawo la ubongo lomwe lili ndi ubongo ndi cerebellum).
Palibe mankhwala a maulendo a Pierre Robin. Kusamalira chikhalidwechi kumaphatikizapo kuchiza zizindikiro za munthu aliyense. Nthawi zambiri nsagwada imakula mofulumira m'chaka choyamba cha moyo ndipo kawirikawiri imawoneka mwachibadwa pafupi ndi sukulu ya sukulu. Kukula kwachilengedwe kumapanganso machiritso alionse omwe amatha kupuma. Nthaŵi zina njira yowonongeka (monga njira yopita kumsewu kapena pamlomo) imayenera kugwiritsidwa ntchito kwa nthawi. Mankhwala odzola ayenera kukonzedwa opaleshoni chifukwa angayambitse mavuto pakudyetsa kapena kupuma. Ana ambiri omwe ali ndi maonekedwe a Pierre Robin adzafuna mankhwala othandizira.
Kulemera kwa kayendedwe ka Pierre Robin kumasiyana mosiyana pakati pa anthu monga momwe anthu ena angakhale ndi zizindikiro zingapo zomwe zimayenderana ndi vutoli pamene ena akhoza kukhala ndi zizindikiro zambiri zofanana.
Matenda a mtima kapena pakati amanjenje amatha kukhala ovuta kwambiri kuposa mavuto ena omwe amagwirizana ndi Pierre Robin. Kafukufuku wasonyeza kuti njira ya Pierre Robin yokhayokha, (ngati matendawa amapezeka popanda matenda ena), nthawi zambiri sichiti chiopsezo chakufa, makamaka pamene mavuto a mitsempha ya mtima kapena m'mitsempha sakhalapo.
> Zotsatira:
> Cleft Palate Foundation. Zotsatira za Pierre Robin. http://www.cleftline.org/parents-individuals/publications/pierre-robin-sequence/
> Medline Plus. Zotsatira za Pierre Robin. https://www.nlm.nih.gov/medlineplus/ency/article/001607.htm
> Kupititsa patsogolo. Pierre Robin Syndrome. http://emedicine.medscape.com/article/844143-overview#a4