Matenda a Lynch kapena khansara yosabadwa yopanda malire (HNPCC) imapangitsa kuti pakhale ngozi yowonjezera khansa ndi khansa zina. Thandizo lachipatala komanso ndondomeko yowononga khansa ikhoza kuthetsa vutoli.
Lynch Syndrome (HNPCC), Genetics, ndi Amuna Amtundu wa khansa
Pafupifupi 75 peresenti ya khansa ya coloni ndizosawerengeka. Izi zikutanthauza kuti iwo alibe chidziwitso choyambitsa matenda kapena mbiri yakale ya banja kwa munthu yemwe ali ndi matendawa.
Zina mwa zifukwa zina za khansa ya coloni ndi matenda a Lynch kapena khansa yosabadwa yopanda malire (HNPCC).
Matenda a Lynch amawerengetsera 2-7% ya milandu yambiri ya khansa yomwe imapezeka ku US. Popeza kuti pafupifupi 160,000 anthu amapezeka ndi khansa ya coloni chaka chilichonse, izi zikutanthauza kuti pakati pa 3,200 ndi 11,200 za khansa zamtunduwu zimakhudzidwa ndi matenda a Lynch.
Kuwonjezera pa chiopsezo chachikulu cha khansa ya m'mimba, anthu omwe ali ndi matenda a Lynch akhoza kukhala ndi chiopsezo chowonjezereka kuti adziwe khansa zina, kuphatikizapo khansa ya rectum, m'mimba, matumbo aang'ono, chiwindi cha gallbladder ducts, chapamwamba cham'mitsempha, ubongo, khungu, prostate, chiberekero ( endometrium), ndi mazira. Mabanja omwe Lynch syndrome alipo amakhala ndi mbiri yolimba ya banja la khansa. Ndi kuyesa kwa majini kukhala ochuluka kwambiri, mabanja ambiri amadziwa kuti ali ndi kusintha kwa chibadwa kumene kumayambitsa Lynch syndrome.
Ichi ndi chifukwa chake nkofunikira kulemba mbiri ya banja lanu.
Kawirikawiri anthu samaganizira za khansa monga cholowa, koma akawonjezeredwa pamodzi chiwonetsero chikuwoneka.
Kodi Lynch Syndrome Inalandidwa Bwanji?
Matenda a Lynch aperekedwa kuchokera kwa makolo kupita kwa ana chifukwa cha kusintha kwa majini anayi: MLH1, MSH2, MSH6, ndi PMS2. Genesis ndi buku lothandizira kumanga thupi la munthu.
Pafupifupi selo lililonse m'matupi athu lili ndi makope awiri a jini. Chikho chimodzi chimabwera kuchokera kwa amayi anu ndi kopi imodzi imachokera kwa abambo anu. Mwanjira iyi, ngati mayi kapena abambo ali ndi kusintha kwa jini limodzi kapena zambiri zomwe zimachititsa Lynch syndrome, iwo akhoza kupatsira kusintha kwa ana awo, pamene akudutsa ma jini awo.
Kwa matenda ena, ngati imodzi mwa makope awiri a jini yowonongeka kapena yosowa, ina, yabwino, ikhoza kugwira ntchito bwino ndipo sipadzakhalanso nthenda kapena kuwonjezeka kwa matenda. Izi zimatchedwa kuti autosomal recessive pattern .
Matenda ena, kuphatikizapo matenda a Lynch, ngati ngakhale imodzi ya ma jini yowononga kapena yosowa, izi zowonjezera chiopsezo kapena kuyambitsa matenda. Izi zimatchedwa chitsanzo chachikulu cha autosomal. Komabe, nkofunika kukumbukira kuti kokha kowopsa kwa khansara ndi cholowa mwa anthu omwe ali ndi matenda a Lynch. Khansara palokha siinatengedwe ndipo sikuti aliyense amene ali ndi matenda a Lynch adzakhala ndi khansa.
Kuwonjezera pa matenda a Lynch, palinso zina zomwe zimagwirizanitsa khansa yamtundu womwe ndi yofunika kumvetsetsa ndipo ndizowonjezeranso kuti zowonjezereka zimapezeka posachedwa.
Chitetezo Chanu Chabwino Kwambiri
Mwamwayi tikukhala mu nthawi imene simukuyenera kudikirira ndikuwona.
Pali njira zowunika za majini, ndipo ngakhale ngati wina ali ndi chiopsezo cha chibadwa, tikuphunzira zambiri za njira zina zochepetsera chiopsezocho. Kukhala ndi mbiri ya banja la khansa sikuli chinthu choipa pamene chimapatsa anthu kusamalira thanzi lawo. Chitsanzo cha izi ndi khansa ya m'mawere, yomwe pafupifupi 10% ali ndi chiyanjano. Akazi omwe ali ndi mbiri ya banja nthawi zambiri amaonetsetsa kuti amawonedwa ndipo samadikirira kuti awonongeke. Ngati iwo ali ndi khansa, zimatha kupezeka kale kusiyana ndi munthu wina wa 90% amene alibe nkhawa chifukwa cha kusowa kwa mbiri ya banja.
Kulingalira za chikonzero chothandizira mwa njirayi kwathandiza anthu ena kuthana ndi vuto lawo.
Uphungu Wachibadwa
Ngati mupeza kuti muli ndi matenda a Lynch, lankhulani ndi dokotala wanu za kupeza chithandizo kuti muwone uphungu wambiri. Dokotala wanu akhoza kukuthandizani kupeza mthandizi wa ma genetic woyenera m'deralo kapena mukhoza kufufuza webusaiti ya National Society of Genetic Counselors kuti mupeze zothandizira uphungu wa ma genetic. Kuwona mlangizi wa zamoyo n'kofunika chifukwa sikuti kusintha konse kwa majeremusi omwe akukhudzidwa kumabweretsa chiŵerengero chofanana cha khansa. Zosintha zina zingapangitse chiwopsezo kokha, pomwe kusintha kwina kungawonjezere kwambiri chiopsezo cha khansa. Ndikofunika kudziŵa nokha pangozi yanu kuti mutha kupanga ndondomeko yoyendetsera.
Kuyeza kansa
Gawo lachiwiri lofunika kuti mutenge ndikulankhula ndi dokotala wanu za dongosolo la kuyang'anira khansa. Kwa mitundu yambiri ya khansa, kuphatikizapo khansa ya coloni, mayesero owonetsera mosavuta amakhalapo. Ndipo ngakhale za mitundu ya khansa yomwe ilibe mayeso owonetsera, zida ngati CT ndi ma MRI zingagwiritsidwe ntchito kupeza khansa kumayambiriro kwambiri, pamene imachiritsidwa kwambiri.
Monga dzina la khansa lopanda chilolezo losabadwa ndi popolyposis limasonyeza kuti, matendawa amachititsa kuti matenda a khansa asagwiritsidwe ntchito popanda kuwonjezera chiopsezo cha mapuloteni. Mapuloteni ndi kukula mu coloni kuti ngati osatengeredwa, akhoza kukhala khansa yamtundu. Izi sizikutanthauza kuti anthu omwe ali ndi matenda a Lynch sakhala ndi polyps. Zimangosonyeza kuti nthawi zambiri zimakhala ndi khansa ya m'magazi popanda kuyamba kupanga mapepala. Pachifukwachi, kuyang'ana kolonoscopy kwa matendawa kungakhale kovuta kwambiri, koma kafukufuku amathandiza kuti colonoscopy imvetsetse khansa yamtundu wokhudzana ndi matenda a Lynch. Colonoscopy ndi mbali yofunika yothetsera matenda a Lynch.
Mwinamwake mukufunika kuyang'aniridwa kuyambira ali wamng'ono komanso mobwerezabwereza kuposa anthu omwe alibe Lynch syndrome. Ngakhale kuti izi zingawoneke ngati zovuta kwambiri, ndi njira imodzi yabwino yothetsera vuto lanu la khansa, kuphatikizapo khansa ya coloni.
Pali Uthenga Wabwino Wina
Ngakhale kuti palibe amene akufuna kukhala ndi matenda a Lynch, pali uthenga umodzi wokha wokhudzana ndi chikhalidwechi. Mu 2008, ofufuza a ku Italy anafalitsa kafukufuku wosonyeza kuti odwala matenda a khansa omwe ali ndi Lynch syndrome amathandiza kwambiri kuposa odwala ena a khansa. Anthu omwe ali ndi matenda a Lynch amakhala ndi moyo wabwino kwambiri, ndipo 94% mwa odwalawa adakali ndi moyo zaka zisanu pambuyo powapeza, poyerekeza ndi zaka 5 zomwe zimakhalapo ndi 75% kwa omwe ali ndi khansara yam'mimba . Pali zifukwa zambiri zowonjezera izi, kuyambira pakuzindikira koyamba kwa anthu omwe ali ndi matenda a Lynch chifukwa ndi bwino kuti athe kupeza kansa ya kolononi yosiyanitsa mitundu yambiri ya khansa yamtunda. Mwanjira iliyonse, iyi ndi nkhani zolimbikitsa.
Zotsatira
Coalition Coalition Yoyenda Kwambiri. Lynch Syndrome. .http: //fightcolorectalcancer.org/prevent-it/risk-factors/lynch-syndrome
Zotsatira za Gene. Kansera Yowonongeka Osati Polyposisoni. http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=hnpcc
Malo Odziwitsa Zachibadwa ndi Odwala. Kupezeka: 02/21/16. http://rarediseases.info.nih.gov/GARD/
Lindor NM. Kupanga mulandu wa colonoscopy yowonongeka mu matenda a Lynch. Matenda Odziwika, 2009 11: 131-32.
National Institutes of Health. Lynch Syndrome. http://ghr.nlm.nih.gov/condition=lynchsyndrome