Akazi omwe ali ndi UTIs omwe amatha kupindula adzapindula
Chidwi cha katemera wa UTI chinayaka m'zaka za m'ma 1950, ndipo kuyambira pamenepo, ofufuza akhala akuyang'ana katemera wodalirika womwe umalepheretsa mabakiteriya E. coli kusamalitsa chikhodzodzo ndikuyambitsa matenda. Mu July 2017, a FDA anapatsa chithandizo chachangu cha Sequoia Sciences 'FimCH UTI. Ngati atavomerezedwa, katemera wa FIMCH adzakhala chithandizo choyamba cha katemera ku UTI ku United States.
Malingana ndi FDA:
Kuchita mwatsatanetsatane ndi njira yokonzera chitukuko, ndi kuyendetsa ndondomeko ya mankhwala kuti athetse mavuto aakulu ndi kudzaza zosowa zosayenera zachipatala. Cholinga ndi kupeza mankhwala atsopano kwa wodwala kale. Njira Yopititsa patsogolo imayankhula mndandanda wa zovuta zambiri.
Chiyambi
Kuwonjezeka kwa chiwerengero cha mabakiteriya omwe sagonjetsedwa ndi matenda omwe amachititsa kuti matenda a mkodzo akhale aakulu kwambiri (UTIs) . Ndi UTI, matenda akhoza kukwera kuchokera m'chikhodzodzo (cystitis) mu impso (pyelonephritis). Matendawa akhoza kufalikira m'magazi omwe amawopsa. Kuwonongeka kwa impso, kuchipatala, komanso ngakhale imfa ndi zotsatira za matenda aakulu a UTI osagwidwa.
Chifukwa cha kuopsa kwa thanzi labwino ndi thanzi la munthu aliyense, pakhala pali chidwi chokhazikitsa chithandizo cha katemera kuti chiteteze ma antibiotic osagwira ntchito ndipo motero amaletsa kutero mankhwala oletsa antibiotic. .
Komanso, katemera wa UTI ukhoza kuthetsa ululu ndi zowawa kwa amayi omwe adakumana ndi UTI-makamaka omwe akudwala matendawa, kapena matenda osatha, omwe amatha kukhala ndi moyo wambirimbiri.
Katemera wa FIMCH
Katemera wa FIMCH ndi katemera woteteza antigen omwe ali ndi mapuloteni oteteza tizilombo ta FimH.
Mapuloteni a FimH ndi ofunika kwa E. coli kuti agwiritse ntchito mapepala a mkodzo. Katemerayu amachititsa kuti chitetezo cha mthupi chitetezeke ku chithandizo cha FIMH.
Chifukwa cha kupita patsogolo kwa kuyeretsa kwa mapuloteni komanso kukula kwa mankhwala opangidwa ndi DNA, poyerekeza ndi katemera wambiri, makina oletsa antigen akhala otchuka m'zaka zaposachedwapa. Komanso, katemera wodwala wa antigen akhoza kuphatikizidwa.
Ma antigen omwe amagwiritsidwa ntchito mu katemerawa akhoza kufotokozedwa mwa njira imodzi. Choyamba, ofufuza angagwiritse ntchito mafoni (ie, mu vivo) kapena zitsanzo zamtundu. Chachiwiri, pogwiritsa ntchito katemera wotsutsa, ochita kafukufuku amatha kufotokoza ma antigen omwe amagwira ntchito bwino. Katemera wa FIMCH unapezedwa pogwiritsa ntchito zitsanzo za nyama.
Katemera wa FIMCH si watsopano. Poyambirira anali ndi chilolezo ndi Medimmune ndipo analowerera gawo I ndi mayesero a chigawo chachiwiri asanatuluke ku chitukuko. Chofunika kwambiri, katemerayu ankawoneka wotetezeka pa nthawi yoyesedwa. Sequioa Sciences ndiye analoleza katemera, anasintha adjuvant, ndipo adalowa mayesero a chipatala. Mankhwalawa amalembedwa ndi katemera ndipo amagwiritsidwa ntchito popititsa patsogolo kuyankha kwa chitetezo cha mthupi.
Zindikirani, mayesero a chipatala cha phase I ndi maphunziro omwe amafunsa pakati pa anthu 20 ndi 100 kuti ayesetse chitetezo ndi mlingo wa mankhwala.
Mayesero amachigawo a Phase II amapempha anthu mazana angapo kuti awone zomwe zimachitika ndi mankhwala. Mayesero otsogolera a Gawo III angaphatikizepo anthu zikwizikwi ndikuwonanso mphamvu komanso kuyang'anira zotsatira zovuta.
Malingana ndi mauthenga a mawapoti, pa nthawi ya Sequoia mayesero anga a katemera wa FIMCH, katemerayo analoledwa bwino ndipo amachititsa kuti munthu akhale ndi mphamvu yowonongeka. Kwenikweni, akazi okwana 67 analandira katemera. Mwa akaziwa, 30 adali ndi mbiri ya UTI yomwe idatha zaka ziwiri. Mwachidziwikire, zotsatira za mayesero awa a chipatala cha 1 ine sizinasindikizidwe mokwanira m'mabuku.
Ndani Ayenera Kupewa Vaccinated?
Azimayi amene amatha kupeza kachilombo ka HIV nthawi zonse amakhala oyenera ku katemera wa UTI.
Cystitis, kapena matenda a chikhodzodzo, amakhala pafupifupi 90 peresenti ya UTI zonse. Pakati pa 20 ndi 30 peresenti ya akaziwa amatha kubwereza miyezi itatu kapena inayi. Zotsatira za UTIs zowonjezereka zimakhala zopweteka kwambiri komanso zopweteka ndipo zimawathandiza kuti maantibayotiki asamatsutse chifukwa amayi omwe ali nawo nthawi zambiri amamwa maantibayotiki m'kati mwa chaka.
Ali ndi Katemera Wina Atayesedwa Posachedwapa?
GlycoVaxyn ndi Janssen Pharmaceuticals akhala akugwiritsanso ntchito katemera wina wotchedwa UTI wotchedwa ExPEC4V, yemwe ndi wofunsira katemera wa E coli ooconjugate wolemera kwambiri. Mu February 2017, Huttner ndi olemba anzawo adamasula zotsatira kuchokera ku mayesero a phase 1 a katemera wa katemera.
Azimayi okwana 93 adalandira katemera ndipo amayi 95 analandira malo otchedwa placebo. Ophunzirawo anali pakati pa zaka 18 ndi 70 ndipo anali ndi mbiri ya UTIs yobwerezabwereza. Katemerayu ankaloledwa bwino ndi olandira. Kuwonjezera apo, katemerawa amachititsa kuti anthu ambiri asamadziwe bwino, ndipo amayi omwe analandira katemerawa anali ochepa kwambiri chifukwa cha EDI yomwe inayambitsidwa ndi E. coli.
Pomaliza, panthawi ya mayesero, chipatala cha FIMCH chawonetsa lonjezo poletsa UTIs oyambitsa E. coli. Pakalipano, chisankho chovomerezera katemera uyu chikuyendetsedwa ndi FDA. Ngati atavomerezedwa, katemerayu adzateteza tizilombo toyambitsa matenda a antibiotic ndipo adzathandiza makamaka amayi omwe ali ndi UTIs omwe nthawi zonse.
> Zotsatira:
> FDA. Mwatsatanetsatane. www.fda.gov
> Gupta K, Trautner BW. Matenda a Mitsempha ya Urinary, Pyelonephritis, ndi Prostatitis. Mu: Kasper D, Fauci A, Hauser S, Longo D, Jameson J, Loscalzo J. eds. Mfundo za Harrison za Internal Medicine, 19e New York, NY: McGraw-Hill.
> Huttner, A, et al. Kutetezeka, kuteteza thupi, kusamalitsa thupi, ndi njira yoyenera yochizira katemera woteteza Esitrichia coli mwa amayi omwe ali ndi mbiri ya kachilombo ka HIV kamodzi komwe kamakhala kosavuta, kamodzi kokha, kamene kalibe kalikonse. Matenda Opatsirana a Lancet. 2017; 17 (5): 528-537.
> O'Brian, VP, et al. Mankhwala ndi Chitukuko Chothandizira Kuchiza ndi Kupewa Matenda Otsata Madzi. Mafilimu a Microbiology. 2016.