Dronedarone (Multaq) ndi mankhwala osokoneza bongo amene anapangidwa pofuna kuchiza matenda opatsirana pogonana . Pofunafuna mankhwala abwino ndi ogwira mtima pa vutoli, makampani opanga mankhwala akhala akuganiza kale grail yawo yoyera: mankhwala omwe amagwira ntchito monga amiodarone , koma alibe poizoni wapadera. Dronedarone inapangidwa ndi Sanofi (opanga a amiodarone) makamaka mwa chiyembekezo cholenga graya woyera.
Mphamvu
Monga mankhwala osokoneza bongo amapita, dronedarone imathandiza kwambiri pochiza matenda oopsa. Tsoka ilo, izi sizinena zambiri. Mayesero angapo a zachipatala asonyeza kuti dronedarone imathandiza kwambiri kukhalabe ndi chizoloŵezi chachibadwa kwa anthu omwe ali ndi matenda oopsa.
Makamaka, dronedarone yasonyezedwa kukhala yothandiza kwambiri kuposa placebo. Komabe, 64 peresenti ya odwala omwe ankadwala ndi dronedarone anali ndi matenda opatsirana mobwerezabwereza m'chaka choyamba cha mankhwala. Mosiyana ndi zimenezi, odwala 75% omwe analandira placebo anali ndi mavitamini othawa mankhwala. Kupititsa patsogolo uku modzichepetsa kumakhala kofanana ndi komwe kunawonedwa ndi mankhwala ena ambiri oletsa kugonana - kachiwiri, sizikutanthauza zambiri.
Mu kuyesa kwachipatala poyerekeza ndi mphamvu ya dronedarone ndi amiodarone, dronedarone inali yocheperapo ndi mankhwala ake "kholo". Anthu 64 mwa anthu 100 aliwonse omwe ali ndi matenda a atrial opangidwa ndi dronedarone anali ndi matenda opatsirana pogwiritsidwa ntchito pa chaka chimodzi, poyerekeza ndi "okha" 42% omwe amachitira mankhwala a amiodarone.
Kodi Dronedarone Amaletsedwa Bwanji?
Dronedarone ndizochokera kwa amiodarone, yomwe imakhala yogwira mtima kwambiri, koma mankhwala owopsa kwambiri omwe amachititsa kuti ayambe kukhala ndi mankhwala osokoneza bongo. Mosiyana ndi amiodarone, dronedarone alibe ma atomu a ayodini. Amakhulupirira kuti ayodini ya amiodarone imapanga mankhwala enaake oopsa, makamaka chithokomiro cha mankhwala a chithokomiro omwe amapezeka ndi mankhwala komanso mwina poizoni wa m'mapapo .
Ndipo pamene izo zikutembenukira, dronedarone sinawonetsere mtundu waukulu wa toxicities wokhudzana ndi amiodarone. Komabe, chiwerengero cha poizoni chadzidzidzi chimakhala ndi dronedarone, ndipo matenda ena a poizoni awonetsanso. Anthu omwe ali ndi vuto la chiwindi kapena mapapu pa amiodarone sayenera kupatsidwa dronedarone.
Kafukufuku wasonyeza kuti anthu omwe ali ndi vuto la mtima , kapena amene asiya tizigawo ting'onoting'ono tomwe timakhala tizilombo ta 35% kapena m'munsimu, akhoza kukhala ndi chiopsezo cha imfa podzatenga dronedarone. Dronedarone sayenera kugwiritsidwa ntchito kwa anthu okhala ndi izi.
Zotsatira zina zoyipa za dronedarone zikuwoneka ngati zosavuta. Zotsatira zambiri zomwe zimachitika ndi zotsekula m'mimba kapena mseru, kuchepa mtima kwa mtima, ndi kuthamanga.
Mfundo Yofunika Kwambiri
Monga mankhwala osokoneza bongo, dronedarone ayenera kugwiritsidwa ntchito mosamala. Ntchito yake yogwiritsidwa ntchito ndi kuthandiza kuthandizira kukhala ndi mtima wabwino kwa odwala omwe ali ndi zizindikiro za matenda a atrial fibrillation . Ngati mafinyria akuthawa panthawi yomwe akutenga dronedarone, mankhwalawa ayenera kuimitsidwa, ndipo njira yothandizira inayambitsidwa.
Mankhwalawa amagwiritsidwa ntchito kwambiri kwa achinyamata omwe ali ndi matenda okhaokha omwe ali ndi ma ARV komanso omwe ali ndi mitima yathanzi.
Werengani zambiri zokhudza chithandizo cha mankhwala oopsa .
Mawu Ochokera
Monga zatulukira, dronedarone si graya woyera. Zoonadi, nkhani yomwe ili ndi mankhwalawa ndi nkhani yomweyi yomwe yamvapo kawirikawiri ndi mankhwala osokoneza bongo - chisangalalo choyamba, chotsatira chisokonezo chachikulu. Monga gulu, mankhwala osokoneza bongo amathandiza kwambiri, komabe ndi ena mwa mankhwala oopsa kwambiri ochizira mankhwala. Ayenera kugwiritsidwa ntchito pokhapokha atapenda mosamala njira zonse, ndipo phindu limene lingapindulitse limakhala bwino kwambiri kuposa zoopsa kwenikweni.
> Zotsatira:
> Dorian P. Clinical Pharmacology Ya Dronedarone: Zopweteka Kwa Therapy Of Matenda Atheria. J Cardiovasc Pharmacol Ther 2010; 15:15.
> H Hockie SH, Crijns HJGM, van Eickels M, et al. Zotsatira za dronedarone pa zochitika za mtima m'magetsi oopsa. N Engl J Med 2009; 360: 668-678.
> Connolly SJ, Camm AJ, Halperin JL, et al. Dronedarone ali ndi chiopsezo choopsa cha matenda opatsirana pogonana. N Engl J Med 2011; DOI: 10.1056 / NEJMoa1109867.