Ngozi ndi zotsatira za Celebrex za mankhwala a migraine
Celebrex - dzina lachilendo celecoxib - ndilo mtundu wa antisteroidal anti-inflammatory kapena NSAID . Zimagwira ntchito polimbana ndi kutupa kwa prostaglandin m'thupi, potero kumachepetsa ululu. Ngakhale kuti kawirikawiri amagwiritsidwa ntchito kuchiza nyamakazi , madokotala ena amati Celebrex ndi mankhwala ovuta kwambiri.
Kodi Celebrex Imasiyana Bwanji ndi NSAID Yachikhalidwe?
Celebrex imalowera puloteni mu thupi lotchedwa COX-2, yomwe imayambitsa kutentha thupi.
Ibuprofen ndi naproxen, kumbali inayo, amagwiritsa ntchito michere COX-2 ndi COX-1 - kotero amatchedwa NSAID osasankha. COX-1 ndi enzyme yomwe imathandiza kukhala ndi chida cha m'mimba ndi m'matumbo.
Ngakhale kuti NSAID ikhoza kuchepetsa kupweteka ndi kutukumula pakuwombera COX-2, zimatha kuvulaza m'mimba ndi m'mimba, zomwe zimachititsa kuti m'mimba muzizira magazi komanso zilonda zam'mimba. Pofuna kuwongolera mwachangu COX-2, Celebrex imachepetsa vuto la m'mimba ndi m'mimba.
Kodi Celebrex Imaperekedwa ndi Odwala Matenda a Edzi a Migraines?
Ngakhale kuti NSAID zimatengedwa ngati mankhwala oyamba a mitsempha yovuta, palinso kusamala komwe amagwiritsidwa ntchito ndi madokotala ambiri polemba Celebrex. Izi zimachokera ku kuchotsedwa kwa ziwalo zina za COX-2 zochokera kumsika, monga Vioxx (rofecoxib), chifukwa chogwirizana ndi mavuto a mtima.
Tsopano NSAID zonse, kuphatikizapo Celebrex, zimakhala ndi chenjezo la boxed kuti chiwopsezo chachikulu cha matenda a mtima, monga matenda a mtima ndi kupwetekedwa mtima.
Izi zikunenedwa kuti, Celebrex ikhoza kukhala njira yothandizila pa mankhwala achimake, makamaka kwa anthu omwe ali pachiopsezo cha NSAID chifukwa chovulazidwa m'mimba ndi m'mimba. Pofuna kutsimikizira mfundo imeneyi, phunziro limodzi laling'ono la 2007 ku Singapore Medical Journal linapeza kuti 400mg ya celecoxib inali ofanana ndi 550mg naproxen pofuna kuchepetsa migraines yovuta - ndipo celecoxib inachititsa ululu wochepa m'mimba kuposa naproxen.
Kodi Ena Akufunsa Chiyani Dokotala Wanu Angakufunseni?
Mofanana ndi mankhwala alionse, ndikofunika kukambirana za zoopsa ndi zotsatira zake zonse ndi dokotala wanu. Nazi zitsanzo za mafunso angapo dokotala wanu angakufunseni:
- Ndi mankhwala ena ati amene mukuwatenga? Mankhwala ena amagwirizanitsa ndi Celebrex kapena kuwonjezereka kwake zowonjezera zotsatira.
- Kodi muli ndi chifuwa chilichonse? Mwachitsanzo, simuyenera kutenga Celebrex ngati mwakhala ndi mphumu, ming†™ oma, kapena ngati simunayanjane ndi NSAID m'mbuyomo.
- Kodi muli ndi vuto lililonse lachipatala? Mwachitsanzo, Celebrex sayenera kuperekedwa kupyolera mwa opaleshoni.
- Kodi muli ndi pakati? Celebrex sayenera kugwiritsidwa ntchito m'mayendedwe amtsogolo a mimba.
Zovuta Kwambiri za Celebrex
Izi zimafuna kuti muthandize dokotala wanu mwamsanga ndikuphatikizapo:
- Kusokoneza (kupuma kupuma, kutseka kwa khosi, kutupa kwa milomo yako, lilime, kapena nkhope, kapena mng'oma)
- Kupweteka kwa m'mimba, chifundo, kapena kukhumudwa
- Zozizira zamagazi, zakuda, kapena zala
- Mphuno kapena kupweteka kwa mtima
- Matanzi a magazi
- Kulemera kosawerengeka kosadziwika
- Kutupa kapena kuchepetsa madzi
- Zosavuta zachilendo kapena zamantha
- Kuthamanga kwa khungu kapena kuyabwa
- Khungu la khungu lanu kapena maso anu
- "Zizindikiro zofanana ndi chimfine."
- Kudula kapenanso kutuluka mwadzidzidzi
Chifukwa cha zomwe zingapangitse kuti chiopsezo cha mtima chiziwonjezeka komanso kupwetekedwa ndi Celebrex ndi zina zopanda aspirin NSAIDs, monga ibuprofen ndi naproxen, ndikofunikira kupeza chithandizo nthawi yomweyo ngati mukumva kupweteka pamtima, kupuma, kuperewera pa gawo limodzi kapena mbali thupi, kapena mawu osokoneza.
Zina zowopsa kwambiri zotsatira zake zimaphatikizapo kugwidwa, kutsegula m'mimba, chizungulire, kuzizira. Ndikofunika kuonana ndi dokotala ngati muwona zotsatira zina zomwe zimabweretsa mavuto, zotsutsana, kapena zokhudzana ndi inu kapena ena.
Kodi izi zikutanthauza chiyani?
Ngati dokotala akulembera Celebrex pa migraines yanu, mungaipeze m'mimba mwanu kuposa Aleve (naproxen) kapena Motrin (ibuprofen).
Zotsatira
American Academy of Neurology. Malangizo Otsatira Umboni wa Kumutu kwa Mutu wa Migraine Kumalo Oyang'anira Kusamalira Msinkhu: Kusamalidwa kwa Mavitamini Akumenyana Kwabwino. Idabweretsanso December 2, 2015.
FDA. FDA imavomereza celecoxib yoyamba ya generic. Idatsidwa December 2, 2014.
Hawkey CJ. COX-1 ndi COX-2 inhibitors. Malo Odyera Opambana Otchedwa Resct Res Gastroenterol. 2001 Oct; 15 (5): 801-20.
Loder E, Burch R, Rizzoli P. Zotsatira za 2012 AHS / AAN zothandizira kupewa matenda a epradic migraine: mwachidule ndi kuyerekezera ndi njira zina zamakono zachipatala. Mutu . 2012; 52: 930-45 .
Loo CY, Tan HJ, Teh HS & Raymond AA. Randomized, label yotseguka, kuyesedwa kuyesedwa kwa celecoxib pochiza matenda ovuta a migraine. Singapore J J. 2007 Sep; 48 (9): 834-9.
US Food and Drug Administration. (July 9, 2015). FDA Drug Safety Communication: FDA imachenjeza kuti mankhwala osagwiritsa ntchito aspirin omwe si anti-inflammatory (NSAIDs) angayambitse matenda a mtima kapena kukwapula.
US Food and Drug Administration. Njira Zothandizira Mankhwala Osakaniza Steroidal Anti-Inflammatory (NSAIDs).