Chithokomiro chodziwika bwino monga chithokomiro, chithokomiro cha chithokomiro, ndi chithokomiro cha porcine-ndi mankhwala a chithokomiro omwe amachokera ku chithokomiro chouma cha nkhumba.
Chithokomiro chokongoletsedwa mwachilengedwe chinali mankhwala oyambirira opangidwa kuti azichiza matenda a hypothyroidism ndipo akhalapo kwa zaka zopitirira zana.
Shift kwa Levothyroxine
Kwa theka la zaka zana la makumi awiri, lachilengedwe lopangidwa ndi chithokomiro-ndiko, chizindikiro chotchedwa Armor Thyroid-ndicho chithandizo chokha chopezeka kwa hypothyroidism.
M'zaka za m'ma 1950, mtundu wa thyroxine (T4) unapangidwa. Thyroxine ndi imodzi mwa mahomoni awiri ofunikira chithokomiro chimatulutsa. Izi zotchedwa thyroxine zimadziwika kuti levothyroxine, kapena l-thyroxine, ndipo inalimbikitsidwa ngati njira yamakono yogwiritsira ntchito hypothyroidism, poyerekezera ndi chithokomiro chodziwika bwino.
Mosiyana ndi levothyroxine, yomwe imapanga timadzi timene timatulutsa timadzi timene timatulutsa timadzi timene timatulutsa timadzi timene timatulutsa timadzi timene timatulutsa timadzi timene timatulutsa tizilombo t4 (thy4xine) ndi T3 (triiodothyronine) komanso calcitonin. Matenda a chithokomiro amatha kupanga makamaka T4 (hormone yosungirako) ndi zina T3, ndipo T4 imasanduka T3, hormone yogwira ntchito, kuti igwiritsidwe ntchito ndi maselo ndi ziphuphu za thupi.
Levothyroxine wakhala akuthandizidwa kwambiri ndi mankhwala ochiritsira ochiritsira kuyambira kale. (Ena mwa malonda odziwika bwino a levothyroxine ndiwo Synthroid, Tirosint , Unithroid, ndi Levoxyl).
Zachilengedwe zowononga mankhwala a chithokomiro, kuphatikizapo dzina lachilengedwe Chachilengedwe-Throid, Chithokomiro WP, Chithokomiro cha Zida, ndi Acella ya mankhwala a chithokomiro achibadwa a NP Nroid, akhalabe pamsika. Mankhwalawa akupitiliza kukopa kutsutsidwa ndi moto kuchokera kwa madokotala odziwika bwino ndi makampani oyendetsa mankhwala, omwe amati ndi "akale" komanso osakhalitsa.
Pakalipano, odwala chithokomiro akupitirizabe kukonda chithokomiro pa levothyroxine, mwinamwake chifukwa cha mavitamini a T4 ndi T3 omwe ali ndi kachilombo koyambitsa matenda, monga T4 mu levothyroxine.
Zochitika Zachilengedwe Zowonongeka ndi Levothyroxine
Nkhani ya chithokomiro, yomwe imatulutsa kachilomboka, ndi levothyroxine yakhala ikutsutsana kwa zaka zambiri. Ngakhale kuti ntchito ya levothyroxine inayamba ntchito, atangoyambitsa levothyroxine, madokotala nthawi zambiri ankatsutsana ndi kugwiritsa ntchito mankhwala osokoneza bongo, kunena kuti panalibe maphunziro omwe amasonyeza kuti ndi otetezeka kapena ogwira ntchito.
Kwa mafanizidwe a chilengedwe chonchi, panali uthenga wofunikira kwa odwala chithokomiro omwe adatuluka mu Msonkhano Wachigawo wa Endocrine Society, womwe unachitikira mu June 2013 mu San Francisco. Malinga ndi kafotokozedwe ka Thanh D. Hoang, KODI, ogwira ntchito zachipatala a Walter Reed National Hospital Medical Center ku Bethesda, MD, mankhwala omwe amadziwika ndi mankhwala a chithokomiro amakhala othandizira njira yothandizira mankhwala otchedwa levothyroxine.
Phunziro ili, Dr. Hoang adapanga phunziro losavuta, lachiwiri, lopindika, poyerekeza ndi chiwopsezo cha chithokomiro chodziwika bwino ndi lavothyroxine monga chithandizo cha hypothyroidism.
Kafukufukuyu anayeza odwala 70, omwe ali ndi zaka 18 mpaka 65, ndipo onse anali ndi hypothyroidism. Odwalawo anapatsidwa mwayi wopita ku gulu limene linatengera mankhwala osokoneza bongo kapena levothyroxine, kwa masabata 16. Maphunzirowa anali akhungu, kutanthauza kuti odwala sankadziwa kuti ndi mankhwala ati omwe amalandira.
Pamapeto pa phunziroli, odwalawa anafunsidwa kuti ndi mankhwala ati omwe amakonda. Chochititsa chidwi, pafupifupi theka la gulu-makamaka, makumi asanu ndi anayi-makumi asanu ndi limodzi (49 peresenti) amatchula chithandizo cha chithokomiro chodziwika bwino, poyerekeza ndi pafupifupi 19 peresenti omwe ankakonda levothyroxine.
Pafupifupi 33 peresenti ya odwala sanatchulepo zomwe amakonda.
Chochititsa chidwi kwambiri: Dr. Hoang ananenanso kuti odwala omwe amatenga chiwopsezo amataya pafupifupi mapaundi atatu panthawi yophunzira, poyerekeza ndi odwala omwe akudwala levothyroxine, omwe sanataya cholemera chilichonse.
Dr. Hoang anauza Endocrine Masiku ano :
Sitinapeze kusiyana kulikonse pakati pa mankhwala ochizira pakati pa mankhwala awiri ... Ife tsopano tikudziwa kuti kamodzi katsiku kamatchulidwa kachipangizo ka chithokomiro ndi njira yabwino yothandizira odwala omwe ali ndi hypothyroidism omwe sakhutira ndi mankhwala a levothyroxine. Ndizofuna kuti iwo ayesere, komanso kuti azisakanizidwa angapangitse odwalawa kuchepa kwenikweni.
> Chitsime:
> Hoang TD, et al. "Zophatikizapo za chithokomiro poyerekeza ndi levothyroxine pochizira hypothyroidism: kuphunzira kosawerengeka, kosaona, kosavuta." J Clin Endocrinol Metab. 2013 May; 98 (5): 1982-90. do: 10.1210 / jc.2012-4107. Epub 2013 Mar 28.