Udindo wa Angiogenesis mu Kukula kwa Khansa

by Lynne Eldridge, MD

Angiogenesis ndi Inhibitors mu Chithandizo cha Khansa

Tanthauzo: Angiogenesis

Angiogenesis imatanthawuza kupanga mapangidwe atsopano a magazi m'thupi. Ndi njira yachibadwa ya machiritso komanso imathandizira kukula kwa khansa.

Angiogenesis mu Health ndi Healing

Angiogenesis ndi njira yachibadwa yomwe imachitika m'thupi paliponse pamene kukula kwa mitsempha yatsopano imayenera.

Choncho, ndi kofunika kuti ana akule, chifukwa chiberekero cha uterine chimakula mwezi uliwonse kwa amayi omwe ali ndi zaka zambiri, komanso mabala kuti achiritse.

Angiogenesis mu Cancer ndi Metastasis

Angiogenesis ndi chidwi ndi khansara chifukwa khansa imafuna kupanga mapangidwe atsopano a magazi kukula ndi kuchepetsa mphamvu. Kuti khansa zikhale zazikulu kuposa 1 millimeter (1 mm) angiogenesis iyenera kuchitika. Khansa imachita izi pobisa zinthu zomwe zimayambitsa angiogenesis, ndipo kotero, kukula kwa khansa.

Kuphatikizapo kukhala njira yofunikira kuti khansa ikulire ndikuukira zida zoyandikana nazo, nkofunikira kuti mitsemphasi ichitike . Kuti maselo a khansa ayende ndi kukhazikitsa nyumba yatsopano kwinakwake kupatulapo kumene akuchokera, maselowa amafunika kubweretsa mitsempha yatsopano kuti akathandize kukula kwa malo awo atsopano.

Angiogenesis ndi Vascular Endothelial Growth Factor (VEGF)

Mitsuko ya magazi imapangidwa ndi maselo otchedwa endothelial cells mkati mwa ziwiyazo.

Zinthu zomwe zimadziwika kuti mapeto azomwe zimakula, VEGF mwachidule, zimakhala ngati zizindikiro zomwe zimathandiza maselo otsirizira kukula ndikupanga mitsempha yatsopano. Mwa kuyankhula kwina, iwo ndi oyambitsa. Momwe zimapangidwira mwazi m'thupi, monga ntchito zambiri, ndizomwe zimayambitsa zowonongeka ndi zoletsa.

Angiogenesis Inhibitors

Angiogenesis inhibitors ndi mawonekedwe a chithandizo chamankhwala , chomwe chimatanthauza kuti makamaka amagwira maselo a khansa kapena maselo ofunikira kuti kukula kapena kufalikira kwa khansa.

Mankhwalawa akhoza kusokoneza njira ya angiogenesis pazigawo zosiyanasiyana. Zina mwazi ndizoletsedwa kuti zisawonongeke kuti maselo amatha kukula, motero amaletsa mapangidwe atsopano a magazi.

Zitsanzo za Angiogenesis Inhibitors

Zina mwa angiogenesis inhibitors zomwe zilipo pakadwala khansa ndizo:

Avastin (bevacizumab)
Nexavar (sorafenib)
Sutent (sunitinib)
Otsatira (pazopanib)
Afinitor (everolimus)

Phunzirani zambiri zokhudza immunotherapy ndi momwe angiogenesis inhibitors amagwira ntchito pofuna kuchiza khansa.

Angiogenesis Inhibitors Komanso Chemotherapy

Funso lodziwika ndilo chifukwa chake anthu amafunikira chemotherapy kuwonjezera pa angiogenesis inhibitors. Kuyang'ana momwe angiogenesis inhibitors amagwirira ntchito kumathandizira kufotokoza izi. Angiogenesis inhibitors sizimapha khansa, zimangowathandiza kuti zisapitirire kukula ndi kufalikira (metastasizing), kotero kuti athetse chifuwa, chemotherapy imayenera kugwiritsidwa ntchito pamodzi ndi angiogenesis inhibitors.

Zotsatira Zotsatira za Angiogenesis Inhibitors

Pamene angiogenesis inhibitors anali atayamba kupezeka ngati mankhwala a khansa, ankaganiza kuti sangakhale ndi zotsatira zochepa.

Sizinali choncho. Monga momwe chemotherapy imayambitsa zotsatira zoyipa ndi zochita zake pa maselo achilendo (mwachitsanzo, poletsa kupatulidwa kwa maselo m'matumbo a tsitsi, mafupa, ndi matumbo a m'mimba) angiogenesis inhibitors angayambitsenso zotsatira zokhudzana ndi ntchito zawo mu maselo abwino ndi matenda. Zina mwa zotsatira zofala zokhudzana ndi:

Kuchiritsidwa kosavulaza kwapachiyambi kuyambira angiogenesis inhibitors sikuti kungangowonongeka ndi mphamvu ya maselo a khansa kupanga mitsempha yatsopano ya magazi koma imathanso kusokoneza mphamvu zamatenda wathanzi kuti apange mitsempha yatsopano ya magazi m'malo mwa kuvulaza.

Kuwombera mitsempha, zomwe zingayambitse matenda a mtima ndi zikwapu.
Kuthamanga kwa magazi.

Tsogolo / Zayesero

Mankhwala ambiri m'gulu lino akuyesedwa m'mayesero a zachipatala, ndipo pali chiyembekezo kuti kuyambitsa khansara chifukwa cholepheretsa matenda a angiogenesis kudzakhala mbali yambiri ya mankhwala a khansa m'tsogolomu.

_Zotsatira:

_{American Society of Clinical Oncology.} _Cancer.Net. _{Angiogenesis ndi Angiogenesis Inhibitors Kuti Azichiza Khansa.} _07/2014. _{http://www.cancer.net/navigating-cancer-care/how-cancer-treated/personalized-and-targeted-therapies/angiogenesis-and-angiogenesis-inhibitors-treat-cancer}

_{National Cancer Institute.} _{Angiogenesis Inhibitors.} _{Kusinthidwa 10/07/11.} _{https://www.cancer.gov/about-cancer/treatment/types/immunotherapy/angiogenesis-inhibitors-fact-sheet}