Kodi Ndingatani Ngati Ndikudwala Matenda Aakulu?
Kodi Taxotere (docetaxel) amagwira ntchito bwanji komanso nthawi yanji pofuna kuchiza khansa ya prostate ?
Kodi Taxotere (Docetaxel) Zimagwira Ntchito?
Taxotere (docetaxel) amagwira ntchito mofanana ndi mankhwala ambiri a mankhwala am'madzi powasokoneza maselo (otchedwa mitosis). Popeza maselo a khansa ndi ena mwa maselo omwe amagawidwa mofulumira kwambiri m'thupi, maselowa amakhudzidwa kwambiri ndi zochita za Taxotere ndipo, motero, amafa pamtunda pamene mankhwalawa akugwiritsidwa ntchito.
Kuwonjezera pa kansa ya prostate, Taxotere ingagwiritsidwe ntchito kwa anthu omwe ali ndi khansa yamapapu, khansa ya m'mawere, kapena khansara ya ovari.
Mbiri - Taxotere ya Kansa Yotsutsa Kwambiri ya Prostate
Taxotere inabweretsedwa m'kati mwa mankhwala opatsirana khansa ya prostate pambuyo pa kafukufuku wofalitsidwa ku New England Journal of Medicine mu 2004 yomwe inasonyeza kuti Taxotere kuphatikizapo steroid prednisone inachititsa kuti munthu apulumuke bwino poyerekeza ndi mankhwala omwe amakhalapo pamtundu wa kansa ya prostate yapamwamba , mitoxantrone. Nyuzipepala ya New England Journal inasonyezanso kuti amuna omwe ankagwiritsidwa ntchito ndi Taxotere anali ndi moyo wabwino kwambiri komanso kuti azitha kupweteka kwambiri. Panthawi imeneyo, Taxotere ankaonedwa kuti ndi chithandizo cha kusankha kwa kansa ya prostate yapamwamba mwa amuna omwe kansa ya prostate inafalikira patali pa prostate ndipo inali yotsutsana ndi mankhwala a mahomoni .
Taxotere amachitabe kuti ndibwino kusankha (kuphatikizapo mankhwala ena omwe akuwerengedwa) kuti agwiritsidwe ntchito kwa amuna omwe ali ndi kansa ya prostatic yomwe yakhala yosagwirizana ndi mankhwala a hormone (androgen suppression therapy.)
Pakalipano - Taxotere ya Early Hormone-Sensitive Metastatic Khansa ya Prostate
Maphunziro aakulu monga mayesero a CHAARTED pakati pa ena asintha njira yoyamba ya khansa ya prostate yowonongeka ndi mahomoni ambiri kwa amuna ambiri. Mankhwalawa akhoza kukhala ovuta kwambiri panthawi yomwe akudziwunikira kapena atakhala ndi masewera pambuyo pa mankhwala oyamba a kansa ya prostate .
Ngakhale kuti mankhwala a Taxotere anali atagwiritsidwa ntchito kwa amuna omwe ali ndi khansara yotchuka ya prostate omwe anali atagonjetsedwa ndi mankhwala otchedwa hormonal treatment, zikuwoneka kuti pogwiritsa ntchito mankhwala a Taxotere kumayambiriro - panthaŵi imodzimodzi yomwe mankhwala opatsirana ndi mahomoni amayamba - ali ndi ubwino pa zonse zopita patsogolo kupulumuka ndi moyo wonse. Ndithudi, Taxotere ili ndi zotsatira zoyipa za nkhawa monga mankhwala alionse a chemotherapy, koma izi, kuphatikizapo kupita patsogolo pogwiritsira ntchito mankhwala ena, ndi chizindikiro chosangalatsa cha chitukuko cha mankhwala a kansa ya prostate.
Kodi Mungatani Ngati Mukudwala Matenda Aakulu?
The STAMPEDE Trial analembera amuna omwe ali ndi kansa ya prostate yapamtunda. Amuna omwe anapatsidwa Taxotere pa nthawi ya mankhwala opangira mahomoni anapezeka kuti ali ndi matenda abwino komanso opulumuka kwambiri kuposa omwe anachiritsidwa ndi mankhwala okhaokha. Nkhokwe ndi yakuti amuna omwe ali opambana kwambiri pa chithandizochi ndi omwe ali ndi khansara ya prostate.
Chithandizo cha Adjuvant kwa Khansa ya Puloteni Yam'mudzi Yoopsa
Kwa amuna omwe ali ndi prostate yapamtunda omwe ali ndi chiopsezo chachikulu, pogwiritsa ntchito Taxotere mu malo amodzi (ngati "chochitika") amapezeka kuti amachepetsa kwambiri chiwerengero cha khansa ya prostate ya kutali.
Amunawa anachiritsidwa ndi Taxotere kuphatikizapo mankhwala opatsirana pogwiritsa ntchito mankhwala komanso ma ARV , osati mankhwala opatsirana ndi ma ARV. Inde, Taxotere ili ndi zotsatira zina zomwe zimayenera kuganiziridwa.
Kodi Ndi Zotsatira Zotani?
Mofanana ndi mankhwala onse a mankhwala a chemotherapy, pali zotsatira zosiyanasiyana zomwe zingachitike mukatenga Taxotere. Mwinanso mukhoza kudziŵa zina mwazimene zimakhala ndi mitundu yambiri ya mankhwala a chemotherapy. Zotsatira zotsatirazi zimachitika mwa magawo atatu mwa anthu atatu omwe amagwiritsa ntchito Taxotere:
- Neutropenia - Kuchuluka kwa maselo oyera a magazi omwe angayambitse matenda.
- Matenda a m'magazi - Kuwerengeka kwa maselo ofiira a m'magazi omwe angayambe kutopa pakati pa zizindikiro zina.
- Kutaya tsitsi
- Kusungirako zamagetsi
- Kutsekula m'mimba
- Nausea - Chizindikiro ichi nthawi zambiri chimayang'aniridwa bwino ndi mankhwala omwe akupezekapo pakamwa
- Kuthamanga
- Zilonda zamkati
- Fingernail amasintha
- Zomwe zimayambitsa - Izi ndi zachilendo, ndipo mankhwala oletsa zizindikiro zowopsa zimaperekedwa limodzi ndi kulowetsedwa.
Zotsatira:
Fizazi, K., Jenkins, C., ndi I. Tannock. Kodi docetaxel ikhale yoyenera yothandizira odwala omwe ali ndi kansa ya prostate yovomerezeka ndi maselo? Pro ndi kutsutsana. Annals of Oncology . 2015. 26 (8): 160-7.
Goodman, A. Docetaxel Ophatikizidwa ndi Mankhwala a Hormone Akuwonjezera Kupulumuka mu Khansara yapamwamba ya Prostate. Post ASCO . http://www.ascopost.com/issues/may-25,-2015/docetaxel-combined-with-hormone-therapy-extends-survival-in-advanced-prostate-cancer.aspx.
James, N., Sydes, M., Clarke, N. et al. Kuonjezera kwa docetaxel, zoledronic acid, kapena zonsezi ku mzere woyamba wa mankhwala a kansa ya prostate (STAMPEDE): zotsatira zapulumuka kuchokera kumayesero osinthika, ochulukirapo, ochulukirapo, ochuluka, omwe akuyendetsedwa mosasintha. Lancet . 2015 Dec 21. (Epub patsogolo pa kusindikiza).
Martel CL, Gumerlock PH, Meyers FJ, et al. Njira zamakono zowonongeka kwa khansa ya prostate yowonongeka ya prostate. Khansa Pitirizani Rev. 2003; 29: 171-187.
National Cancer Institute. Kufufuza kwa ndalama za NIH kumapangitsa kuti anthu apitirizebe kukhala ndi matenda a kansa ya prostate yomwe imalandira mankhwala a chemthro. http://www.cancer.gov/news-events/press-releases/2013/E3805.
Tannock IF, de Wit R, Berry WR, et al. Docetaxel kuphatikizapo prednisone kapena mitoxantrone kuphatikizapo prednisone ya kansa ya prostate yapamwamba. N. Engl. J. Med. 351 (15): 1502-12.