Ma mesothelium ndiwo matenda omwe amamanga ndi kuteteza ziwalo za m'chifuwa, m'mimba, ndi m'mimba.
Chikhalidwe
Maselo a Mesothelial amayamba ngati mesoderm panthawi ya chitukuko (mapapo amachokera ku endoderm) ndipo mwachiwonekere amachititsa mbali yofunikira pakukula kwa mapapo.
Mesothelium imagawidwa m'madera atatu oyambirira:
- Phokosoli ndi ma memphane omwe amapanga mapaipi m'mapapo. Izi, zigawanika, zimagawidwa pa pepala la visceral pleura limene limakhala pamapapo, komanso phokoso la parietal, lomwe lili kunja kwa mapaipi.
- Powicardium imatanthawuza mesothelium yomwe imapanga ziboda pamtima ndi mediastinum , malo omwe ali pachifuwa pakati pa mapapo.
- Peritoneum imaphatikizapo mndandanda wa mesothelium yomwe imayika pamimba pamimba. Dera limeneli lidagawidwa m'magawo awiri. Phiri la perceroneum limayendera ziwalo za mkati, ndi parietal peritoneum, yomwe imazungulira makoma ndi m'mimba.
Ntchito
Nthaŵi ina ankaganiza kuti cholinga chokha cha mesothelium chinali kupereka malo otsekemera, osalumikizira kuti ateteze ziwalo za chifuwa ndi mimba pamatenda ndi kupuma.
Tsopano tikuphunzira, zomwe zikufanana ndi matani ndi zowonjezereka, mesothelium ili ndi ntchito zina zofunikira, komanso zimagwira ntchito ngati chiwalo cholimba osati kungokhala malire omwe amalola kuyenda moyenda bwino.
Izi zikuphatikizapo:
- Kutengerako ndi kayendetsedwe ka madzi ndi nkhani pamphindi kuchokera kunja kwa chifuwa ndi m'mimba ziwalo kwa ziwalo za mkati. Poyendetsa ntchitozi, minofu ya mesothelial ikhoza kugwira ntchito yofunikira kwambiri panyumba.
- Coagulation (magazi clotting)
- Machiritso
- Ntchito yoteteza thupi kuthupi - Ma mesothelium amawoneka kuti ali ndi chitetezo choteteza matenda komanso kufalikira kwa zotupa. Maselo amtundu wa mesothelial maselo omwe amateteza mabakiteriya, kuphatikizapo omwe ali ndi chifuwa chachikulu.
- Chitetezo pa zotupa - Maselo a Mesothelial amawoneka ngati mankhwala omwe amalepheretsa kukula kwa ziwalo za m'mimba. Zinthu izi zimawoneka kuti ziletsa mphamvu ya maselo a khansa kuti "amangirire" kwa mesothelium, ndipo motero, kuchepetsa kufalikira kapena ma metastasis a zotupa zina.
Zochitika Zamankhwala
Mesothelioma ndi mtundu wa khansara yomwe imayambira mu mesothelium (kumadera alionse kumene mesothelium ilipo.) Khansara iyi imapezeka mwa anthu omwe akhala akupezeka ndi asibesitosi ( onani kuopsa kwa asibesitosi ,) ndipo akupitirira kuwonjezeka kuchitika padziko lonse lapansi.
Zizindikiro za mesothelioma zingaphatikizepo chifuwa, zovuta kumeza, kupweteka m'mimba ndi kuphulika, ndi zizindikiro zina malingana ndi malo a chotupacho. Njira yopaleshoni yotchedwa pleurodesis (kuchotsedwa kwa pleura) nthawi zina imachitidwa pofuna kuchotsa chotupacho, ngakhale kuti matendawa ndi osauka panthawi yomwe khansayo imapezeka.
Mavuto ndi opaleshoni yamba ya opaleshoni ya m'mimba.
Minofu ya ma mesothelioma m'mimba ya m'mimba ingapangitse magulu a minofu, yomwe imatha kumangirira ndi kubisala. Zizindikiro za kumatira zimakhala zowawa m'mimba, kupondaponda, ndi kuphulika. Ngati ma adhesion ndi ofewa (osayambitsa zowonongeka kwathunthu) anthu amatha kudwala matenda opweteka m'mimba, makamaka atadya chakudya chambiri.
Fibrosis - Ofufuza tsopano akufufuzira udindo umene mesothelium yodandaula ikhoza kugwira nawo mu fibrosis, makamaka mikhalidwe monga idiopathic pulmonary fibrosis .
Pleural effusions kapena build-up of fluid pakati pa zigawo ziwiri za pleura (pleation mesothelium) zimakhudzidwa ndi zinthu zobisika ndi maselo a mesothelial wodandaula.
Zotsatira:
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Kasper, Dennis L .., Anthony S. Fauci, ndi Stephen L .. Hauser. Mfundo za Harrison za Mankhwala a M'kati. New York: maphunziro a Mc Graw Hill, 2015. Print.
Kumar, Vinay, Abul K. Abbas, ndi Jon C. Aster. Mabala a Robbins ndi Cotran Pathologic Mavuto a Matenda. Philadelphia: Elsevier-Saunders, 2015. Print.
Mikula-Pietrasik, J., Uruski, P., Kucinska, M., Tykarski, A., ndi K. Ksiazek. Ntchito Yotetezera ya Maselo a Mesothelial Kukula kwa Peritoneal Mimba Zogwira Ntchito: Udindo wa Solomoni ICAM-1. International Journal ya Biochemistry ndi Cell Biology . 2017. 86: 26-31.
Mutsaers, S., Prele, C., Pengelly, S., ndi S. Herrick. Maselo a Mesothelial ndi Peritoneal Homeostasis. Utsi ndi Wofooka . 2016. 106 (5): 1018-1024.