Senescence kwenikweni amatanthauza "njira yakukalamba." Zimatchulidwa ngati nthawi ya kuchepa pang'ono komwe kumatsatira gawo la chitukuko mu moyo wa munthu. Kotero chisamaliro pakati pa anthu chikhoza kuyamba nthawi yanu mu zaka za 20, pamphamvu ya mphamvu yanu, ndikupitiriza moyo wanu wonse.
Mawu akuti "senescence" amachokera ku liwu lachilatini senex, kutanthauza "ukalamba." Mu moyo wautali ndi masinkhu okalamba , senescence ndi kuchepa kwa thanzi ndi ntchito yogwirizana ndi ukalamba.
Pali ziganizo zingapo zomwe zimabwera nthawi zambiri, kuphatikizapo senescence yamagetsi ndi organismal senescence .
Kodi Cell Senescence Ndi Chiyani?
Pamene maselo sangathe kupatukana chifukwa cha kuwonongeka kwa DNA kapena kuchepetsedwa kwa telomere , amapyola kusintha komwe kumapangitsa kuchepa kapena kuwonongeka. Maselo amadziwononga okha (otchedwa apoptosis ) kapena amapita nthawi yochepa (yotchedwa senescence ).
Chotsatira chachikulu chotsiriza ndicho selo imfa, yomwe ndi gawo labwino la ntchito zamoyo ndipo imapezeka nthawi zonse m'thupi lanu.
Maselo a kansa amaganiziridwa kuti ndi maselo omwe sagwiranso ntchito ya senescence m'malo mwake, pitirizani kufotokozera ndikupangitsa mavuto (ndi zotupa). Ndipotu, ofufuza akuyesetsa kupanga mankhwala omwe amachititsa kuti maselo a khansa ayambe kukalamba monga maselo obadwa - mwazinthu zina, asayansi amafuna kupanga chiwalo cha maselo ambiri mumaselo ngati njira yothetsera khansara.
Thupi lanu ndi Senescence
Ngakhale kuti senescence ya maselo ikhoza kukhala chinthu chabwino chifukwa maselo amapitirizabe kudzichotsera okha, thupi lanu lidzapita nthawi yochepa yotchedwa organismal senescence (mwazinthu zina, senescence wa zamoyo).
Monga ndanenera pamwambapa, njirayi ikuyamba pamene thupi lanu likukula bwino ndipo muli ndi mphamvu, ndipo akupitiriza moyo wanu wonse.
Mwa mtundu uwu wa senescence, kuwonongeka kwa thupi lanu kumayamba kusokoneza mphamvu ya thupi kugwira ntchito. Kusokoneza uku kumayambitsa zotsatira zomwe timayanjana nazo ndi ukalamba.
Kutalika Kwambiri, Kukalamba Kwambiri, ndi Senescence
Sayansi siinapeze njira yothetsera chisamaliro cha senescence monga chokhudzana ndi anthu, ndipo ena ofufuza (ngakhale si onse mwa njira iliyonse) amanena kuti sitidzatha kuimitsa.
Koma tikhoza kuimitsa. Cholinga chanu, ndiye, kuchepetsa njira ya senescence momwe zingathere. Mungathe kuchita izi ndi:
- Kudya Chakudya Chopatsa thanzi: Izi zimapangitsa thupi lanu kukhala ndi zakudya zomwe zikufunikira kukonzanso kuwonongeka ndikupewa kuwonongeka kwa mtsogolo.
- Kuchepetsa Kupsinjika Maganizo: Izi zimalepheretsa kuwonongeka kwa nthawi yaitali kuchoka pamtundu wambiri ku mahomoni opsinjika komanso kuthupi komwe amapanga.
- Pewani Kuwonongera Zomwe Zimapweteka: Izi zimathandiza kuchepetsa kuchuluka kwa zinyama za thupi lanu. Pewani kuyang'ana kwambiri ku magetsi a UV, kuipitsa, ndi poizoni.
- Kugwiritsa Ntchito Zambiri: Izi zimathandiza thupi lanu kumanga matenda amphamvu omwe amaletsa kuwonongeka.
- Kupewa Matenda: Onaninso dokotala wanu kuti azifufuza nthawi zonse ndikusunga magazi anu, kulemera kwake komanso zinthu zina zoopsa.
Zotsatira:
Campisi J. Aging, senescence ya ma cell, ndi khansa. Kukambirana kwa Pakati pa Physiology. 2013; 75: 685-705.
Dimri GP et al. Kodi senescence yakhudzana ndi khansa yotani? Kansa Cell. 2005 Jun; 7 (6): 505-12.