Majini omwe mumakhala nawo kwa makolo anu amadziwoneka maonekedwe anu, monga mtundu wa diso ndi mawonekedwe, komanso zizindikiro zina, monga mtundu wamagazi ndi kuyang'anitsitsa. Ndipo sizo zonse. Zamoyo zogonjetsa zingathandizenso kuzindikiritsa mphamvu zina za thupi lanu - monga kuteteza khansa ya prostate kuti isabwererenso.
Mmene Khansara ya Prostate ikukula
Androgens (mahomoni ogonana) amachititsa khansa ya prostate kukula.
Choncho, androgen deprivation therapy (ADT) ndi njira imodzi yothetsera khansa ya prostate , makamaka ikapitirira kapena ikufalikira. ADT ikhoza kuphatikizapo kumwa mankhwala omwe amachititsa androgen kuti asapangidwe (m'matumbo) kapena kuletsa zotsatira za androgen mu thupi lanu lonse. ADT imatha kuphatikizapo opaleshoni kuchotsa matenda onsewa. Kawirikawiri amagwiritsidwa ntchito kuwonjezera pa mankhwala ena a khansa ya prostate, monga mankhwala othandizira poizoni kapena prostate.
ADT, makamaka, imachotsa mafuta ndikuletsa maselo a khansa ya prostate kuti isakule - kapena kuchepetsa.
Koma, nthawi zambiri, ADT imagwira ntchito kwa nthawi yaitali. Maselo a khansa ya prostate nthawi zambiri amakhala "osakanikirana" mosakwanira. Amayamba kupanga azitsulo zawo, potero amapanga mafuta okhaokha.
Amuna amene amalandira ADT kwa khansa ya prostate amakhala ndi machitidwe afupipafupi a prostate-specific antigen (PSA) . Mapangidwe a PSA angasonyeze kuti khansara ya prostate yakhala yosagonjetsedwa ndipo yayamba kukula.
Zobadwa Zina Zisamalire Mphamvu Yanu Yopewera Khansa ya Prostate
Amuna ena amatha kugwiritsa ntchito ADT kusunga kansa ya prostate pamtunda kuposa ena.
Phunziro la 2016 ku Cleveland Clinic ndi kuchipatala cha Mayo linapeza kuti amuna omwe ali ndi mitundu yosiyanasiyana ya jini amatha kukhala ndi kansa ya prostate yosagonjetsedwa posachedwa. Mwa amuna awa, ADT siigwira ntchito motalika.
Khansara yawo idzafulumira.
Kuchokera kwa odwala khansa ya prostate ya 443 mu phunziroli, onse anali ndi matenda aakulu ndipo anachiritsidwa ndi ADT. Amuna ena anali ndi majeremusi a HSD3B1 "obadwa" - makope awiri, mmodzi kuchokera kwa kholo lililonse. Ena anali ndi kusiyana, HSD3B1 (1245C), koma kuchokera kwa kholo limodzi. Enanso anali ndi jini yosiyana kuchokera kwa makolo onsewo.
Mitundu yambiri ya jini, ya ADT yocheperako inagwira ntchito.
Anthu omwe ali ndi majeremusi "ochibadwa" m'magulu a odwala a Cleveland Clinic adasiya kansa ya prostate kuti ikhale ya zaka 6.6. Enawo sanachite bwino. Amene ali ndi mitundu yosiyanasiyana ya jini kuchokera kwa kholo limodzi adabwereranso zaka zisanu ndi zinayi. Anthu omwe ali ndi mitundu yosiyanasiyana ya jini kuchokera kwa makolo onsewa anagonjetsa zaka ziwiri zokha.
Kodi Muli ndi Gene Yosiyana?
Malinga ndi polojekiti ya 1000 Genomes, pafupifupi theka la amuna ndi akazi a ku United States ali ndi HSD3B1 (1245C) jini-kuchokera kwa makolo kapena onse awiri.
Pakalipano, palibe mayeso osavuta kuti azindikire (ngakhale kuti akhoza kudziwika muzitsulo lathunthu). Kafufuzidwe kafukufuku amafunikanso pamaso pa HSD3B1 (1245C) -wayikidwa pamayeso a magazi.
Bwanji osati tsopano? Chifukwa palibe umboni wokwanira wosintha mankhwala kwa amuna omwe ali ndi jini yosiyana akhoza kusintha zotsatira.
Tikuchita kafukufuku wambiri tsopano kuti tiwone ngati njira zina zothandizira ma hormone zidzagwira bwino kuposa ADT mwa amuna awa. Ngati atero, tidzakhala ndi umboni wakuti kuyesa magazi kumayenera kuperekedwa ku screen kwa HSD3B1 (1245C).
Chithandizo Chodzipangira Chokha Chingakhale Chinthu Chochuluka Kwambiri
Lero timachiza odwala onse omwe ali ndi kansa ya prostate yowonjezera malinga ndi nthawi imodzi yosamalidwa. Koma kufufuza kungatipangitse ife kuti tiwone zochiritsira zokha malinga ndi maonekedwe a mthupi.
M'tsogolo muno, tikuyembekeza kugwiritsa ntchito mayeso a ma gene kuti tipeze kuti odwala amafunika chithandizo chotani, m'malo mochiza aliyense mofanana.
Mwachitsanzo, odwala opanda HSD3B1 (1245C) majini angakhale bwino ndi ADT. Anthu amene ali nawo angafunikire kulandira chithandizo choopsa.
Dr. Sharifi ndi katswiri wa zachipatala ku Cleveland Clinic ku Taussig Cancer Institute ndipo akugwira Kendrick Family Endowed Chair kwa Research Prostate Cancer ku Cleveland Clinic.
> Zotsatira:
> Phunzirani JW, Abuali G, Reichard CA, et al. HSD3B1 ndi kukana mankhwala a androgen-kunyamulidwa mu khansara ya prostate: maphunziro obwereza, maphunziro a multicohort. Lancet Oncol. 2016; 17 (10): 1435-1444.