Momwe Zimagwirira ntchito, Zotsatira Zotsalira, ndi Zambiri
Gabapentin ndi mankhwala omwe amavomerezedwa ku fibromyalgia . Lilipo ngati lachibadwa ndipo limagulitsidwa pansi pa mayina a dzina la Neurontin, Horizant, ndi Gralise.
Gabapentin si FDA yovomerezedwa kuti athetse vutoli, kotero ilo lidaperekedwa kuchokapo. Mankhwalawa amagwirizana ndi Lyrica (pregabalin) , yomwe imavomerezedwa ngati mankhwala a fibromyalgia.
Ndipotu, nthawi zina Lyrica amatchedwa "mwana wa Neurontin."
Gabapentin amadziwika kuti ndi mankhwala osokoneza bongo. Amagwiritsidwa ntchito pochizira matenda a khunyu, kupweteka kwa m'mitsempha (kupweteka kwa mitsempha yowonongeka), matenda a miyendo yopuma , ndi kutentha kwa moto.
Ululu wa Fibromyalgia ndi wofanana ndi matenda a ubongo, koma ngati matendawa amachititsa kuwonongeka kwa mitsempha komabe sikumveka bwino.
Momwe Gabapentin Amagwirira Ntchito
Gabapentin amakhulupirira kuti amagwira ntchito potembenuza kutulutsidwa kwa glutamate ndi zina zotulukira ubongo m'mtima mwanu. Odwala matendawa amapereka mauthenga kuchokera ku selo imodzi ya ubongo kupita ku ina.
Glutamate imathandiza kwambiri pazinthu zina, monga kuphunzira zatsopano. Ndi chifukwa chakuti maselo anu amachititsa kuti ubongo wanu ukhale wolimba.
Komabe, ngati mwana wamng'ono ndi chokoleti, ngati muli ndi glutamate wochuluka kwambiri kumtunda uko, maselo a ubongo angapangidwe kwambiri. Izi zingapangitse mitundu yonse ya zinthu kuyenda molakwika.
Glutamate ali ndi ntchito yoposa imodzi, komabe.
Zimathandizanso kutumiza zizindikiro zopweteka mu ubongo ndi mitsempha yanu. Kulemera kwambiri kwa glutamate kungathandize kwambiri pa hyperalgesia , zomwe zimangotulutsa ululu wa ululu.
Pofuna kuthana ndi zotsatira za glutamate, muli ndi kachilombo kamene kamatchedwa gamma-aminobutyric acid (GABA) . Zimachepetsa maselo anu ndi kuyendetsa ubongo wanu.
Pamene GABA ndi glutamate zilipo mofanana, zinthu zimayenda bwino.
Matenda ndi zikhalidwe zina zingathe kusokoneza chiwerengero ichi ndikulola glutamate kuthamanga amok. Gabapentin amakhulupirira kuti kuchepetsa ubongo wanu kumasulidwa kwa glutamate kotero maselo akhoza kuchepetsa ndipo ubongo wanu ukhoza kugwira bwino bwino.
Gabapentin kwa Fibromyalgia
Kafukufuku amasonyeza kuti anthu omwe ali ndi fibromyalgia ali ndi glutamate kwambiri m'madera ena a ubongo wawo, kotero kuti gabapentin akhala akulembedwera kwa nthawi yaitali.
Koma kodi ndizothandiza? Kafukufuku ndi wosakanikirana.
Ndemanga ziwiri za umboni sizigwirizana. Mmodzi womasulidwa mu 2016 anapeza kuti gabapentin ndi mankhwala othandiza a fibromyalgia, koma inanso, yomwe inafalitsidwa mu 2017, inanena umboni wochepa chabe.
Kufufuza kwa gabapentin kwa 2014 kwa fibromyalgia ndi matenda a ubongo kunapeza kuti pafupifupi 35 peresenti ya ophunzira omwe adawona kuti kuvutika kwawo kunachepa ndi 50 peresenti panthawi imeneyi. Ndikofunika kudziwa kuti, 21 peresenti adawona madontho omwewo pamene atenga placebo.
Pofufuza kuyerekezera gabapentin ndi pregabalin (mankhwala ku Lyrica), kuphatikizapo imodzi yofalitsidwa mu Journal of the American Medical Association, pregabalin inkaonekera kuti ikhale yabwino.
Gabapentin yowonjezera kutulutsa mawonekedwe akuwonetsa malonjezano muyeso limodzi laling'ono lofalitsidwa mu zowawa .
Ochita kafukufuku amanena kuti kupweteka, kugona, ndi khalidwe labwino zimakhala bwino. Ichi chinali chiyeso choyambirira, komabe, ntchito yambiri imayenera kuchitidwa tisanatsimikizire ngati zakhala zotetezeka nthawi yaitali.
Mlingo wa Gabapentin
Gabapentin nthawi zambiri amayamba pa mlingo wochepa ndipo kenako pang'onopang'ono akuwonjezeka. Onetsetsani kutsatira malangizo a dokotala wanu.
MaseĊµera omwe alipo pakati pa 900 mg ndi 1,800 mg tsiku ndi tsiku, amagawidwa m'magulu atatu.
Musamasiye kumwa gabapentin mwadzidzidzi. Onetsetsani kuti mungalankhule ndi dokotala wanu za njira yoyenera yoyeretsera pa mlingo womwe mukuwutenga.
Gabapentin Zotsatira Zachimake
Mofanana ndi mankhwala onse, gabapentin amadza ndi mavuto.
Zina zimakhala zoopsa pamene ena sali oopsa.
Ngati muli ndi zotsatirapo zotsatirazi pamene mutenga gabapentin, pitani kuchipatala mwamsanga:
- zofooka zazikulu za kutopa
- ululu wam'mimba
- kupweteka pachifuwa
- chifuwa chatsopano kapena chowopsa ndi fever
- kupuma kupuma
- kupsinjika kwakukulu kapena kupweteka
- kuyenda mofulumira, kumbuyo ndi kutsogolo kwa diso
- kupweteka kapena kuvutika ndi kukodza, kapena kusasaka
- malungo
- chikhure
- kutupa nkhope kapena lilime
- kuyaka maso
- kuthamanga
Zotsatira zomwe siziri chifukwa chodandaula mwamsanga ndizo:
- kutopa
- chizungulire
- mutu
- akugona
- phindu lolemera
Ana omwe amatenga gabapentin akhoza kukhala ndi zotsatira zosiyana. Lankhulani ndi dokotala mwamsanga kwa zotsatirazi:
- kusintha khalidwe
- mavuto a kukumbukira
- Kulephera kuganizira
- kusabisa, chidani, kapena kuzunza
Gabapentin akhoza kusokoneza ndi mankhwala ena. Onetsetsani kuti dokotala wanu ndi wamankhwala amadziwa zonse zomwe mukuzitenga.
Kodi Gabapentin Ndi Yoyenera Kwambiri?
Ndi umboni womwe uli wofooka komanso wosakanikirana, gabapentin ali ndi mwayi umodzi kuposa Lyrica-ndizopangidwe, ndipo ndizovuta kwambiri. Kusiyana kwa mtengo kumayendetsa anthu ena kuyesa gabapentin mosasamala kanthu pa kufooka kochepa mu maphunziro.
Komanso, tonse timachita mosiyana ndi mankhwala. Anthu ena omwe amalephera kugwiritsa ntchito mankhwala ena akhoza kupeza mpumulo wa gabapentin.
Ngati mukufuna kuyesa gabapentin, kambiranani ndi dokotala za ubwino ndi kumwa kwa mankhwala komanso momwe zingagwiritsire ntchito mankhwalawa.
> Zotsatira:
> Calandre EP, Rico-Villademoros F, Slim M. Apha2delta ligands gabapentin, pregabalin ndi mirogabalin: kafukufuku wa mankhwala awo azachipatala ndi ntchito zothandizira. Kufufuza kwa akatswiri a matenda a ubongo. 2016 Nov; 16 (11): 1263-1277.
> Cooper TE, Derry S, Wiffen PJ, Moore RA. Gabapentin chifukwa cha ululu wa fibromyalgia mwa akuluakulu. Msonkhano wa Cochrane wa ndemanga zowonongeka. 2017 Jan 3; 1: CD012188.
> Moore RA, Wiffen PJ, Derry S, et al. Gabapentin chifukwa cha ululu wopatsirana mwaukali ndi fibromyalgia mwa akuluakulu. Msonkhano wa Cochrane wa ndemanga zowonongeka. 2014 Apr 27; (4): CD007938.
> Moore A, Wiffen P, Kalso E. Antiepileptic mankhwala opweteka mtima ndi fibromyalgia. JAMA. 2014 Jul; 312 (2): 182-3.
> North JM, Hong KS, Rauck RL. Zotsatira za njira yatsopano yotulutsidwa gabapentin pa ululu ndi kugona mu maphunziro a fibromyalgia: phunziro loyendetsa woyendetsa. Zowawa kuchita. 2016 Jul; 16 (6): 720-9.