Matenda a nyamakazi , matenda omwe amachititsa anthu ku 1.3 mpaka 1.5 miliyoni a ku America, ndi zotsatira za maselo a thupi la thupi lomwe limayambitsa khalala ndi ziwalo. Kodi kwenikweni chimapita bwanji kuchipatala cha munthu yemwe ali ndi nyamakazi kuti amve ululu ndi chiwonongeko chokhudzana ndi matendawa?
Maphunziro a Dr. Julia Ying Wang a Brigham & Women's Hospital ku Boston ndi Harvard Medical School, pamodzi ndi mnzake Dr. Michael H.
Roehrl wa Harvard, adakambidwa pamsonkhano wapachaka wa American Chemical Society mu August 2002 ndipo adafalitsidwa mu PNAS, akuyankhira funso ili.
Zisanayambe ntchito ya Wang ndi Roehrl, kafukufuku wa nyamakazi ya nyamakazi yambiri imayang'ana pa peptide, kapena zidutswa za mapuloteni. Wang ndi Roehrl ankanena kuti glycosaminoglycans, kapena GAGs, ndi zomwe zimayambitsa matenda a nyamakazi m'malo mwa mapuloteni.
Nkhani ya GAGs
Glycosaminoglycans ali ndi zakudya zachilengedwe zomwe zimapezeka m'matumbo , timagulu ting'onoting'ono, timadzi timene timadziphatikiza, komanso khungu. Glycosaminoglycans ndi zakudya zovuta. Sizimakhudzidwa ndi chakudya, chakudya chochepa, ndi shuga zomwe timadya mu zakudya zathu.
Mwachidule, mfundo ya Wang inanena kuti maselo a chitetezo cha mthupi, kapena ma antibodies, amawotcha glycosaminoglycans. Mankhwalawa amamangirira ku GAGs, amadziphatika m'magulu, ndipo amachititsa ululu ndi kutupa komwe kumayambitsa matenda a nyamakazi.
Kafukufuku
Mu phunziro la Wang ndi Roehrl, mbewa zidayikidwa ndi GAGs.
Nthangazi zinayamba kukhala ndi matenda a nyamakazi monga zizindikiro, kuphatikizapo kutupa, kutupa, ndi mafupa.
Matenda a Glycosaminoglycan apezeka kale m'magulu a odwala nyamakazi. Tiyenera kutsindika kuti iyi ndiyo nthawi yoyamba imene glycosaminoglycan antibodies inkawonetsedwa mu nyama kapena anthu.
Ochita kafukufuku anafotokoza kuti:
- GAG zotsutsana ndi mabakiteriya zikhoza kukhala chifukwa cha matenda opatsirana.
- MaseĊµera apamwamba a GAG angayambitse pamene mabakiteriya amapanga tizilombo toyambitsa matenda omwe amathyola minofu yolumikizana ndi kutulutsa chakudya.
- Mabakiteriya ambiri ali ndi GAG m'maselo awo. M'magulu a nyamakazi, maselo a chitetezo amatha kulunjika molakwika ma GAGs omwe amawoneka mwachibadwa m'magulu a thupi momwe angagwiritsire ntchito GAG pamwamba pa opha mabakiteriya.
Ochita kafukufuku ankayembekezera kuti kufufuza kwina kudzawululira njira yodzimangira GAG mankhwala, kutengera mankhwala atsopano kapena mankhwala odwala nyamakazi. Kafukufuku wofalitsidwa mu 2008, mu Arthritis Research & Therapy , adawulula zambiri za GAGS:
- Ma antibodies amtundu wa GAG sapezeka m'matope (ana obadwa).
- GAGs alipo kwambiri mu seramu ya akuluakulu.
- GAGs adagawidwa ngati ma antigen a TI2. Ma cell B1 B amadziwika kuti amatenthetsa ndi ma antigen a TI2.
Zinawululidwanso kuti anti-GAG zowonjezera ma antibodies zimapezeka mwa anthu abwino. Mankhwala a IgM anti-GAG ndi zina za mtundu wa IgG zotsutsana ndi GAG omwe anayesedwa zinawoneka kuti zakwera kwambiri mu sera ya odwala matenda a nyamakazi. Ngakhale anti anti-GAG zowonjezereka zinkakhala pamagetsi, synovial zamadzi komanso ankatha kumanga matrixlalar matrix of cartilage.
Ochita kafukufuku amaganiza kuti mankhwala oletsa anti-GAG ndi "olembedwa" mu nyamakazi ya nyamakazi mwina yokhudzana ndi kutuluka kwa kalotile. Chochititsa chidwi, kupambana kwapakati pa GAG kuli ndi matenda ochepa kwambiri odwala matenda a nyamakazi. Ochita kafukufuku anapeza kuti GAG ingakhale ngati matenda a nyamakazi oyambirira.
Zotsatira:
Glycosaminoglycans Ndizowopsa Chifukwa cha Matenda a Matenda a Khunyu. Proceedings ya National Academy of Sciences ya ku United States of America. Wang JY ndi Roehrl MH. October 21, 2002.
Mavitamini Achilengedwe Amagwiritsidwa Ntchito ndi Glycosaminoglycans mu Chifuwa cha Amuna. Bence Gyorgy et al. Arthritis Research & Therapy. 2008.