Zofukufuku zokhudzana ndi mankhwala a Lupron kapena Provenge poyerekezera ndi khansa ya prostate ya prostate , kuyambira kuchipatala chakumayambiriro kunapangitsa kuti ziwoneka bwino kwambiri. Mofananamo, kufufuza kuwona momwe ntchito yoyambira Taxotere ikuyendera pambuyomo ikuwonetsanso chinthu chomwecho.
Kuyambira Taxotere pa Gawo Loyamba
Taxotere yakhala yopita ku chemotherapy kwa khansa yapakhungu yopanda mahomoni kwa zaka zoposa khumi.
Anavomerezedwa ndi FDA mu 2004 atatsimikiziridwa kuti apitirize kupulumuka. Pambuyo pa mgwirizano wa FDA wa Taxotere, okhawo omwe amapezeka mankhwalawa (Novantrone, Emcyt, ndi Velban) anali amtengo wapatali. Mwachitsanzo, Novantrone ingachepetse kupweteka komanso kusintha moyo. Komabe, sizinakhudze moyo. Taxotere ndi FDA yovomerezeka pambuyo pa mayesero awiri akuluakulu osasinthika atatsimikiziranso mwayi wopulumuka, komabe, kuchuluka kwa kupulumuka kunali kochepa, kokha mwa dongosolo la miyezi ingapo.
Kwa zaka zambiri, akatswiri akhala akudabwa za nthawi yabwino yoyenera kugwiritsa ntchito Taxotere. Kodi ziyenera kuyambitsidwa mutatha kutsutsana ndi Lupron kapena zingakhale bwino kuyambapo musanayambe kusakanikirana kwa mahomoni? Popeza maphunziro apachiyambi omwe amatsogolera ku FDA-avomereza Taxotere adawunikira kuti ali ndi mphamvu zedi kwa amuna omwe kale anali osagonjetsedwa, ndondomeko yomwe adalandira ndi madokotala akuyenera kuti asiye Taxotere mpaka Lupron ikhale yopanda ntchito.
Madokotala angalingalire motere: "Popeza Taxotere ili ndi zotsatira zosiyana, komanso, popeza palibe umboni wosonyeza kuti mankhwala am'mbuyomu ndi othandiza, tidzangoyankha kukonza Taxotere pambuyo pa Lupron kuntchito."
Ndizodziwika bwino kuti anthu ambiri omwe ali ndi kansa ya prostatic prostate amawotcha kuthamanga kwa mahomoni.
Choncho, popeza mankhwala am'mbuyomu kawirikawiri amakhala othandiza, zingakhale zomveka kuganizira zolimbana ndi matendawa pamaso pa maselo osagonjetsedwa ndi mahomoni ochulukirapo ndikuwonjezereka m'magulu osagwira ntchito. Mu 2014 ndi 2015 zotsatira za mayesero awiri a kuchipatala zinayesedwa.
Zotsatira za Maphunziro Aposachedwapa
Phunziro loyamba, CHAARTED (Chemo-hormonal Therapy versus Androgen Ablation Randomised Trial for Extreme Disease in Cancer Prostate), idaperekedwa pamsonkhano wa pachaka wa American Society of Clinical Oncology (ASCO) ndipo inafalitsidwa mu New England Journal of Medicine mu 2015 Izi zasonyeza kuti kwa amuna omwe ali ndi khansara yowonongeka, omwe ali ndi kalembedwe, awonjezeka miyezi inayi ya Taxotere yomwe inayambitsidwa pamodzi ndi Lupron makamaka kuti apulumuka poyerekeza ndi amuna omwe anayamba Lupron okha ndipo anayamba Taxotere pamene Lupron anasiya kugwira ntchito. Mu phunziroli, kupulumuka kwa amuna omwe anachitidwa ndi Taxotere panthawi imodzimodzimodzi ndi Lupron anali ndi miyezi 18 yaitali kuposa amuna omwe poyamba anachitidwa ndi Lupron yekha.
Zotsatira za mayesero ena ofanana, otchedwa STAMPEDE (Syndrome Therapy in Progress or Metastatic Cancer Prostate): Anayesedwa pa msonkhano wa ASCO wa 2015.
Mu phunziro ili pafupifupi pafupifupi 3000 atangodziwika kumene, amuna otchuka a mahomoni, theka la amuna anapatsidwa mwamsanga Taxotere plus Lupron. Kupulumuka kwawo kunayesedwa ndi theka lina lomwe adayamba kulangidwa ndi Lupron yekha. Mofanana ndi maphunziro a CHAARTED, gulu lachiwirili linapatsidwa Taxotere pambuyo pa Lupron. Ndipo kachiwiri, mofanana ndi mayesero a CHAARTED, amuna omwe anayamba Taxotere musanayambe kuthamanga kwa mahomoni anakhalako motalika kwambiri.
Choncho ngakhale kale Taxotere tsopano yakhazikitsidwa nthawi zonse, tsiku ndi tsiku kasamalidwe ka odwala ali ndi khansara ya prostate, momwe mitundu ina ya mankhwala atsopano (monga Zytiga, Xtandi, Xofigo, ndi Jevtana) amasankhidwa kawiri kawiri, chovala, chotsalira.
Kugwiritsira ntchito mankhwala kuchokera motsatizana kapena kuphatikiza kaŵirikaŵiri kumawopsya. Njira yowonongeka imapangitsa kuti, "Zakhala zikuchitidwa motere."
Madokotala amagwiritsa ntchito malingaliro opitirira malire pa zifukwa zambiri ndipo samayesa nthawi zonse "kunja kwa bokosi," njira zamankhwala. Komabe, makamaka tsopano kuti mawotchi atsopano ndi othandizira ali ovomerezeka ndi FDA, kugwiritsa ntchito mankhwala ochiritsira mwachangu amatha kulephera kuthetsa zida zatsopano zogwiritsira ntchito mankhwalawa.