Mu 2011, pamene United States Food and Drug Administration (FDA) inavomereza Benlysta (belimumab) inali chinthu chachikulu! Benlysta anali woyamba kuvomerezedwa ndi mankhwala kwa lupus m'zaka zoposa 50. Pasanapite nthawi, mankhwala okhawo omwe amavomerezedwa ndi FDA kuti athetse lupus anali Plaquenil (hydroxychloroquine), prednisone (1955), ndi aspirin (1948). Koma Plaquenil siinalengedwe ndipo sinagwiritsidwe ntchito kokha kwa lupus. Amatchedwa mankhwala opatsirana pogonana chifukwa amagwiritsidwa ntchito popewera malungo, komanso amagwiritsidwa ntchito pofuna kuchiza nyamakazi.
Mukamamva za Benlysta, nthawi zambiri mumamva mawu a biologic . Mosiyana ndi mankhwala ozunguzidwa ndi mankhwala, biologic ndi mankhwala omwe amapangidwa kuchokera ku chilengedwe monga nyama, anthu, kapena tizilombo toyambitsa matenda. Benlysta ndi wapadera chifukwa zamoyo zina zafika patsogolo pake ndipo zinalephera ngati mankhwala a lupus.
Kuonjezerapo, Benlysta ndiye mankhwala oyamba kulandira lupus. Mankhwala ena omwe amagwiritsidwa ntchito pochizira lupus-like hydroxychloroquine, corticosteroids, methotrexate, azathioprine, cyclophosphamide, ndi mycophenolate mofetil-zinalengedwa kuti zikhale zina zomwe zimapangitsa kuti chitetezo cha mthupi chitetezeke kwambiri. Koma chifukwa Benlysta ali ndi biologic, yopangidwa ndi mapuloteni a anthu, ofufuza adatha kupanga mankhwala omwe angagwire mbali yeniyeni ya chitetezo cha mthupi chomwe chimayambitsa matenda a lupus.
Monga choyamba chokhudzidwa ndi biologic lupus chithandizo, Benlysta satipatsa njira ina yokhayo yothandizira, koma yakhala ikulimbikitsanso kafukufuku watsopano wamakono. Pazifukwa izi, chivomerezo cha FDA cha mankhwala ndi nthawi yofunikira m'mbiri ya lupus kafukufuku!
Mwachibadwa, munthu yemwe amadziwa za Benlysta kwa nthawi yoyamba angafune kudziŵa zambiri za mankhwalawa. M'munsimu muli mayankho a mafunso okhudzana ndi Benlysta.
Kodi Benlysta Amagwira Ntchito Motani?
Malinga ndi Lupus Research Alliance, Benlysta "imagwira ntchito pochepetsa thupi la chitetezo cha chitetezo cha lupus mwa kulepheretsa puloteni yotchedwa 'B lymphocyte stimulator (BLyS)' yomwe imakhulupirira kuti imapangitsa kuti thupi likhale lopweteka kwambiri lomwe limayambitsa ndi kuwononga thupi."
Mwa kuyankhula kwina, BLyS ndi mbali ya chitetezo cha mthupi chomwe chimayambitsa mankhwala. Benlysta amayesetsa kupewa BLyS kuti asayambe kutupa kumene kumayambitsa chitetezo cha mthupi.
Benlysta amagwiritsidwa ntchito pophatikizidwa ndi mankhwala ena a mphu. Kuphatikizidwa kwawonetsa kuti kuli kothandiza kwambiri pochepetsa kuchepa kwa matenda a lupus kusiyana ndi mankhwala okhazikika okha. Zizindikiro zochepetsedwa zimakhudzana ndi khungu, pakamwa, pamphuno ndi minofu, komanso chitetezo cha mthupi.
Chinthu chinanso chopindulitsa cha mankhwala ndi kuchepetsa ntchito ya corticosteroid. Izi ndizofunika kwambiri monga mankhwala a nthawi yaitali, corticosteroids amadziwika kuti amachititsa zotsatira ngati fupa la thupi komanso kuwonongeka kwa thupi.
Kodi Benylsta Amalamuliridwa Bwanji?
Mosiyana ndi mankhwala ambiri a lupus, Benlysta si piritsi. Amagwiritsidwa ntchito ndi kulowetsedwa m'magazi (IV) kapena kupyolera mwa kudzipiritsa.
IV kulowetsedwa
Njira imeneyi imalola kuti mankhwalawa alowe m'magazi ndi kudutsa m'mimba. Ngati adamezedwa mu mapiritsi, amapita m'mimba komanso mapuloteni ofunika omwe amapanga mankhwalawa adzawonongedwa.
Mukayendetsedwa ndi IV kulowetsedwa, simungathe kuzipereka kunyumba ndipo mukuyenera kupita kwinakwake kukalowa mu ofesi monga chipatala, chipatala, kapena malo osungirako mankhwala. Kulowetsedwa kungatenge pafupifupi ola limodzi, koma motalika ngati nthawi yoyenera ndi / kapena nthawi yowonera ikufunika.
Kwa mazunzo atatu oyambirira, ndizochitika kuti zichitike kamodzi pa masabata awiri, ndipo kamodzi pakatha masabata anayi.
Benlysta akuwongolera ngati mankhwala a nthawi yaitali, ndipo ngati iwe ndi dokotala wanu mukugwirizana kuti zikukuyenderani bwino, musati muletse kusamalidwa pamene mukuyamba kumverera bwino. Muyenera kupitiriza chithandizo ngakhale mutakhala bwino ngati njira yopindulitsa.
Kudzivulaza
Panali kuyesetsa kupereka njira yodzipiritsa, kutanthauza kuti mungakhale ndi mwayi wopatsa Benlysta nokha, panyumba. The FDA inavomereza njira yoyamba kudzipiritsa mu 2017, makamaka kwa lupus erythematosus yowonongeka, njira yofala kwambiri ya lupus. Njira yopangira chithandizo imafuna maphunziro pang'ono kuchokera kwa dokotala ndipo ikhoza kukhala yosavuta kusiyana ndi IV kwa ambiri.
Ndamva kuti Silikugwira Ntchito kwa Afirika Achimereka
Maphunziro oyambirira omwe anatsogolera ku Benlysta kuti asangalale nawo sanaphatikizepo anthu okwana Africa ndi America. Izi sizikutanthauza kuti mankhwalawa sangagwire ntchito kwa inu ngati muli African-American. M'malo mwake, zingakhale bwino chifukwa aliyense amene ali ndi lupus ndi wapadera.
Pakalipano pali mayesero ochipatala omwe akuthandizira kuti tiphunzire zambiri za momwe Benlysta aliri wogwira ntchito ku African-American. Mayeserowa ndi ofunika kwambiri popeza amayi a ku Africa-America ali ndi mwayi wokhala ndi lupus kuposa amayi oyera.
Lankhulani ndi dokotala ngati mukufuna kuyesa Benlysta kapena kutenga nawo mbali muyezeso wa Benlysta.
Nanga bwanji ngati ndili ndi mgwirizano wamagulu?
Pamene Benlysta adavomerezedwa ndi a FDA, sankadziwa ngati mankhwalawa angapindule anthu okhala ndi ziwalo monga lupus nephritis kapena central nervous system (CNS) lupus. Komabe, mu kafukufuku wina, anapeza kuti m'zaka zisanu zoyambirira za mankhwala ndi Benlysta, mankhwalawa sanapangitse kapena kuwononga chiwalo, ndipo mwina akhoza kuchepetsa matenda opatsirana pogonana. Popeza izi zinali zokhudzana ndi kafukufuku umodzi womwe unkaphatikiza maphunziro awiri, kufufuza kwina kungakhale kopindulitsa. Kafukufukuwo akulonjeza, kotero ngati muli ndi ziwalo zogwirira ntchito ndipo mukufuna kuyesa Benlysta, kambiranani ndi rheumatologist kuti muwone ngati akuganiza kuti izi ndizo zabwino kwa inu.
Kodi Zotsatirapo Zotani ndi Zowopsa?
Mofanana ndi mankhwala onse, Benlysta akhoza kuwononga zotsatira zake ndipo amadza ndi zoopsa. Kampani ya mankhwala imayenera kuchenjeza za zotsatira zodziwika zotheka, koma izi sizikutanthauza kuti mudzaziwona izi. Ngati mukudandaula za zotsatirapo, nkofunika kuti muyankhule ndi azimayi anu okhudzana ndi mavuto anu. Nthawi zina anthu amakhala ndi zotsatira zoyipa, amasankha kupitiriza chithandizo ngati zotsatira zake sizikhala zovuta kapena ngati iwo ndi dokotala akuwona kuti phindu la mankhwala likuposa zotsatira zake.
Chifukwa cha zoopsa zomwe Benlysta adayambitsa, musanayambe kumwa mankhwalawa, auzeni rheumatologist ngati inu:
- ali ndi zizindikiro za matendawa, matenda a mtima, kapena matenda
- akufunikira kapena atangotenga katemera, makamaka katemera wamoyo
- khalani ndi mankhwala osokoneza bongo
- akugwiritsa ntchito mankhwala ena a biologic, ma antibodies monoclonal kapena IV omwe amatsitsa cyclophosphamide (Cytoxan®)
- ali pa mtundu wina uliwonse wa mankhwala, mankhwala owonjezera, kapena vitamini
- akhala kapena anali ndi mtundu uliwonse wa khansara
- khalani ndi matenda ena
- ali ndi pakati kapena akukonzekera kutenga pakati, kapena ngati mukuyamwitsa
Mfundoyi idzawathandiza dokotala kudziwa ngati Benlysta ndiye mankhwala abwino kwa inu komanso nthawi yabwino kuyamba mankhwala. Mwachitsanzo, ngati muli ndi kachilombo ka HIV, amafunika kubwezeretsa chithandizo chifukwa mankhwalawa akuwonjezera chiopsezo cha matenda.
Ngati zina mwazimenezi zikuchitika mutakhala kale ndi mankhwala, muyenera kuwuzani a rheumatologist wanu.
Pakati pa mayesero a kachipatala, anthu amavutikapo, koma nthawi zonse sizimveka ngati zotsatira zake zimayambitsidwa ndi mankhwala. Komabe, ofufuza-ndipo pa nkhani iyi GlaxoSmithKiline (GSK), omwe amapanga mankhwalawa ayenera kulemba zizindikiro zilizonse zosayenerera zomwe anthu amakumana nazo pamayesero a zamankhwala.
Zotsatira za Benlysta zomwe zimapezeka kwambiri ndizo
- kunyoza
- kutsekula m'mimba
- malungo
- zowonongeka kapena mphuno yothamanga
- chikhure
- chifuwa (bronchitis)
- vuto logona
- kupweteka mwendo kapena kupweteka kwa mkono
- kudandaula
- mutu (migraine)
- matenda oyambitsa mkodzo
- kuchepetsa kuchuluka kwa maselo oyera a magazi (leukopenia)
- kusanza
- ululu wamimba
Ngati mukukumana ndi zotsatira zoopsa izi, nkofunika kuti muwuze katswiri wanu wa rheumatologist pomwepo. Ngati mukukumana ndi zotsatira zoopsa zowopsya, ngati kutayika kumene kumapangitsa kuti mupume, pempherani 9-1-1 mwamsanga.
Pali zina zotheka, zosavomerezeka, zoyipa. Zinalembedwa pa webusaiti ya GSK, koma ndifunikanso kulankhula ndi dokotala wanu wa zaumphawi za zotsatira za Benlysta ndi zoopsa, makamaka.
Mukhozanso kupereka zotsatira zolakwika za mankhwala alionse, osati Benlysta, kwa FDA. Pitani ku www.fda.gov/medwatch, kapena muitaneni 1-800-FDA-1088.
Kodi Ndingakwanitse Kuthetsa Benlysta?
Ngakhale Benlysta ndi njira yamtengo wapatali yotengera mankhwala, GSK imapereka thandizo la ndalama. Katswiri wanu wa rheumatologist angagwire ntchito ndi inshuwaransi yanu ndi GSK kuti mupeze thandizo la ndalama zomwe mukufuna.
Kodi Benlysta Amagwira Ntchito Ana Omwe Ali ndi Lupus?
Sitikudziwikanso ngati Benlysta ali otetezeka komanso ogwira ntchito kwa ana omwe ali ndi lupus. Pali chidziwitso cha mwana wa mwana wa lupus chomwe chimapangitsa kuti Benlysta akhale ndi ana omwe ali ndi lupus pakati pa zaka 5 mpaka 5. Ngati mwana wanu ali ndi lupus, mungathe kuyankhula ndi dokotalayo ngati kuli koyenera kulembetsa phunziro ili.
Kodi Pali Zilibe Zovuta Kwa Benlysta?
Inde. Ngati mungafune zambiri zokhudza Benlysta matenda, mukhoza kulankhula ndi rheumatologist kapena kulankhula GSK mwachindunji. Mukhozanso kupita ku clinicaltrials.gov ndikulemba Benlysta mu bokosi losaka .
Kodi ndizotetezeka kutenga Benlysta kwa nthawi yaitali?
Ofufuza apeza zotsatira za Benlysta mwa anthu amene adatenga mankhwalawa kwa zaka zisanu ndipo apeza kuti, mpaka pano, mankhwalawa ndi otetezeka kutenga nthawiyi. Iwo sanapeze kuwonjezeka kwa zotsatira zodziwika kale.
Kodi Ndingatani Ngati Ndili Woyembekezera Kapena Ndikufuna Kuberekera?
Ngakhale kuti pakhala pali amayi omwe abereka bwino ana omwe ali ndi thanzi labwino pamene akutenga Benlysta, ofufuza akuphunzirabe ngati ndibwino kuti Benlysta akakhala ndi pakati-amachititsa kuti mankhwalawa adutse pamimba ndipo ngati zili choncho, zimakhudza bwanji? Ofufuza asonkhanitsa ndi kusanthula deta zina koma zina zambiri ndizofunikira.
Ngati mutatenga pakati pa Benlysta kapena mkati mwa miyezi inayi mutasiya mankhwalawa, auzani rheumatologist pomwepo, komanso funsani za Belimumab (Benlysta ™) Registry Registry.
Kupyolera mukuwona ndi kusonkhanitsa deta, registry yapangidwa kuthandiza othandizira kudziwa bwino momwe Benlysta amakhudzidwira pa mimba. Inu ndi mwana wanu mudzasamaliranso mosamala mukasankha kukhalabe pa mankhwala.
Nthawi zina, anthu angasankhe kukhalabe pa Benlysta nthawi yonse yomwe ali ndi mimba ngati ubwino wokhala pa mankhwala ndi wamkulu kuposa momwe zingakhalire ndi mwana.
Apo ayi, ndi bwino kugwiritsa ntchito njira zoberekera kuti asatenge pakati pamene akutenga Benlysta, kapena mpaka miyezi inayi atasiya mankhwalawa.
Mofananamo, sizidziwika ngati mankhwalawa achoka kuchokera kwa kholo kupita kwa mwana kudzera mwa kuyamwitsa. Mayi ayenera kusankha pakati pa kuyamwitsa kapena kutenga Benlysta. Ngati mukulingalira kuyamwitsa, chonde lankhulani ndi rheumatologist wanu amene angakuthandizeni kudziwa momwe mungathere.
Kodi Ndingapeze Bwanji Uthenga Watsopano Wokhudza Benlysta?
Kuti mudziwe za kafukufuku waposachedwa kapena nkhani zokhudzana ndi Benlysta, mukhoza kulankhula ndi dokotala wanu. Mukhozanso kuyesa kufufuza pa intaneti, kuonetsetsa kuti mupeze magwero odalirika .
Mu injini yosaka yosankhidwa, mungathe kulowa muyeso lofufuza monga Benlysta kafukufuku 2016 (gwiritsani ntchito chaka chino).
Zotsatira zoyambirira zofufuzira zikhoza kukhala zogwirizana ndi Lupus Research Alliance, kapena mabungwe ena otchuka a lupus. Zitsanzo za malo otchuka a mafunso a lupus ndi MedPage Today ndi Lupus News Today. Izi zingathenso kubwera pakusaka kwanu. (Phunzirani zambiri za momwe mungapezere zambiri zokhudzana ndi umoyo pa intaneti.)
Mungathe kukumana ndi zofalitsa zosindikizidwa ndi GSK. Nthawi zonse zimathandiza kupita ku kampani ya mankhwala ndikuwona zomwe zimasulidwa posachedwapa zokhudza mankhwala enaake.
Ngati mukufuna kupita ku kafukufuku, PubMed ndi webusaiti ya boma ya United States yomwe imapereka mwayi womasuka ku database ya National Library of Medicine yotchedwa Medline. Nthawi zina zimapereka nkhani zokwanira. Nthawi zina zimapereka zizindikiro. Chidziwitso ndichidule cha nkhaniyi.
Ngati mukufufuza pa PubMeb kwa Benlysta, mudzalandira zotsatira zambiri. Mukhoza kupondereza zotsatira mwa kuwonjezera nthawi yanu yosaka. Mmalo mofuna Benlysta , fufuzani zotsatira za Benlysta , mwachitsanzo.
Kodi Benlysta Alipo Pokhapokha ku US?
Kuwonjezera pa kupezeka ku United States, Benlysta ikupezeka m'mayiko asanu ndi limodzi - North ndi South America, Africa, Asia, Europe, ndi Australia. Kuti mudziwe ngati Benlysta alipo m'dziko lanu, lankhulani ndi rheumatologist wanu. Mukhozanso kutchula GSK. Kuti muwawane nawo ngati mumakhala kunja kwa US, pitani ku webusaiti yawo ya Worldwide gawo ndikufufuza ndi dera.
Kodi Benlysta Adzandigwirira Ntchito?
Aliyense amene ali ndi lupus ndi wapadera, kotero palibe yankho losavuta ku funso ili.
Lankhulani ndi rheumatologist wanu kuti mudziwe ngati akuganiza kuti ndinu woyenera pa chithandizochi.
Ngati inu ndi rheumatologist mukuganiza kuti ndi njira yabwino ya chithandizo, muyenera kuyesa mankhwala kuti muwone momwe zikukugwirerani ntchito. Kumbukirani kuti sikugwira ntchito mwamsanga monga mankhwala monga corticosteroids. Zitha kutenga milungu kapena miyezi kuti muyambe kuona zotsatira.
Kuganizira Benlysta? Lankhulani ndi Rheumatologist Yanu
Ngati mukuganiza za Benlysta, chinthu chotsatira ndichokulankhula ndi rheumatologist wanu. Muli ndi mafunso ambiri pamene mukuyamba kukambirana za mankhwalawa, komanso panthawi iliyonse, kuphatikizapo kumwa mankhwalawa. Lembani mafunso anu pamene akukwera, ndipo mubweretse mndandanda wa mafunso anu kumsonkhano wanu wotsatira. Mukhozanso kutchula GSK mwachindunji kudutsa pa BENLYSTA Gateway pa 1-877-4-BENLYSTA (1-877-423-6597) Lolemba mpaka Lachisanu, 8 AM mpaka 8 PM Eastern Time. Pankhani ya thanzi lanu, muli ndi ufulu wodziwa momwe mungathere.
> Zotsatira:
Bruce I, Urowitz M, Vollenhoven R, et al. Kuwonongeka kwa thupi kwa nthawi yayitali ndi chitetezo kwa odwala omwe ali ndi SLE omwe amachitira ndi belimumab mosamala kwambiri. Lupus. 2016; 0: 1-11. http://lup.sagepub.com/content/early/2016/02/18/0961203315625119.full.pdf+html.
> Dubey A, Handu S, Dubey S, Sharma P, Sharma K, Ahmed Q. Belimumab: Chithandizo Choyambirira Chachilengedwe Chakumayambitsa Lupus Erythematosus. Journal of Pharmacology & Pharmacotherapeutics. 2011; Oct-Dec; 2 (4): 317-319. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3198539/.
> Landy H, Powell M, Hill D, Eudy A, Petri M. Belimumab Wolemba Zolemba Mimba: Prospective Cohort Phunziro la Mimba za Mimba. Zovala zamaliseche & Gynecology. 2014; 123 (1). http://journals.lww.com/greenjournal/Abstract/2014/05001/Belimumab_Pregnancy_Registry__Prospective_Cohort.130.aspx.
> Vollenhoven R, Petri M, Wallace J, et al. Mlingo wa Corticosteroid Wowonjezereka Pa Masabata makumi asanu ndi awiri ndi awiri kwa Odwala Amene Ali ndi Lupus Erythematosus Yodalirika: Zomwe Zifufuzidwa Kuchokera Kumayesero a Phase III Belimumab. Arthritis & Rheumatology. 2016; 68 (9): 2184-2192. http://onlinelibrary.wiley.com/doi/10.1002/art.39682/abstract.